CHES-1-like Checkpoint suppressor 1-like [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CHES-1-likeprovided by FlyBase
Official Full Name: Checkpoint suppressor 1-likeprovided by FlyBase
Primary source: FLYBASE:FBgn0029504
Locus tag: Dmel_CG12690
See related: AllianceGenome:FB:FBgn0029504
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Posey7; CG12690; Ches-1-like; ches1; Ches1; Dmches-1; Dmel\CG12690; FoxN; FoxN23
Summary: Enables transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to hypoxia; embryonic heart tube development; and mitotic G1 DNA damage checkpoint signaling. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; gut section; and visceral mesoderm derivative. Orthologous to human FOXN2 (forkhead box N2) and FOXN3 (forkhead box N3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (7682338..7709385, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (7576371..7603418, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

CHES-1-like overexpression in germ cells activates dpp expression, inhibits spermatocyte differentiation, and finally leads to germ cell tumors.
Title: CHES-1-like, the ortholog of a non-obstructive azoospermia-associated gene, blocks germline stem cell differentiation by upregulating Dpp expression in Drosophila testis.
CHES-1-like controls the division of cardiac progenitors by regulating the activity of Polo, a kinase involved in multiple steps of mitosis.
Title: Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G1 DNA damage checkpoint signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Names: CG12690-PA; CG12690-PB; CG12690-PC; CG12690-PD; CHES-1-like-PA; CHES-1-like-PB; CHES-1-like-PC; CHES-1-like-PD; checkpoint suppressor homologue; ches-1-like

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