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    SPR Sex peptide receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31463, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPRprovided by FlyBase
    Official Full Name
    Sex peptide receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029768
    Locus tag
    Dmel_CG16752
    See related
    AllianceGenome:FB:FBgn0029768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12731; CG16752; Dmel\CG16752; DrmSPR; SP-R; spr; Spr
    Summary
    Enables G protein-coupled peptide receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of female receptivity, post-mating; and regulation of egg-laying behavior. Located in plasma membrane. Is expressed in adult brain; adult cervical connective; epithelial tube; ganglia; and uterus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See SPR in Genome Data Viewer
    Location:
    4F11-5A1; 1-11 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5446656..5494012)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5340689..5388045)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44471 Neighboring gene uncharacterized protein Neighboring gene fra mauro Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sexual conflict over remating interval is modulated by the sex peptide pathway. Smith DT, et al. Proc Biol Sci, 2017 Mar 15. PMID 28250180, Free PMC Article
    2. Sexual behaviour: a receptor for sex control in Drosophila females. Kubli E. Curr Biol, 2008 Mar 11. PMID 18334196
    3. Experimental evolution under hyper-promiscuity in Drosophila melanogaster. Perry JC, et al. BMC Evol Biol, 2016 Jun 16. PMID 27311887, Free PMC Article
    4. Sex peptide receptor is required for the release of stored sperm by mated Drosophila melanogaster females. Avila FW, et al. J Insect Physiol, 2015 May. PMID 25783955, Free PMC Article
    5. Mating disrupts morning anticipation in Drosophila melanogaster females. Riva S, et al. PLoS Genet, 2022 Dec. PMID 36548223, Free PMC Article

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decoupled evolution of the Sex Peptide gene family and Sex Peptide Receptor in Drosophilidae.
      Title: Decoupled evolution of the Sex Peptide gene family and Sex Peptide Receptor in Drosophilidae.
    2. Molecular evolution of the sex peptide network in Drosophila.
      Title: Molecular evolution of the sex peptide network in Drosophila.
    3. Drosophila melanogaster sex peptide regulates mated female midgut morphology and physiology.
      Title: Drosophila melanogaster sex peptide regulates mated female midgut morphology and physiology.
    4. Molecular characterization of ligand selectivity of the sex peptide receptors of Drosophila melanogaster and Aedes aegypti.
      Title: Molecular characterization of ligand selectivity of the sex peptide receptors of Drosophila melanogaster and Aedes aegypti.
    5. sex peptide enhances memory by acting on a single pair of serotonergic brain neurons, in which activation of the sex peptide receptor stimulates the cyclic adenosine monophosphate/protein kinase A pathway.
      Title: A sperm peptide enhances long-term memory in female Drosophila.
    6. Study describes for the first time patterns of mating frequency in Drosophila melanogaster SPR- (sex-peptide-receptor is absent in females) and control groups, showing that SPR- females are on average more polyandrous. These results are not explained by the reduced fecundity of SPR- females, suggesting that the observed differences in sexual selection on males are caused by the elevated polyandry of SPR- females.
      Title: Sex peptide receptor-regulated polyandry modulates the balance of pre- and post-copulatory sexual selection in Drosophila.
    7. Data show that female sleep is reduced by male-derived sex Peptide (SP) SP acting through the canonical sex peptide receptor (SPR) within the same neurons responsible for altering other postmating responses (PMRs).
      Title: Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons.
    8. Results suggested that the SP/SPR-mediated post-mating responses was established in the lineage of the D. melanogaster species group.
      Title: Evolution of sex-peptide in Drosophila.
    9. SPR peptide modulates female chemosensory processing upon mating in Drosophila.
      Title: Neuropeptides Modulate Female Chemosensory Processing upon Mating in Drosophila.
    10. important in stabilizing sleep in both males and females
      Title: A homeostatic sleep-stabilizing pathway in Drosophila composed of the sex peptide receptor and its ligand, the myoinhibitory peptide.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 5481114-5485000 mobile_element_type = transposon:I{}62

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled peptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled peptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of female receptivity, post-mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sex peptide receptor
    Names
    CG16752-PA
    CG16752-PB
    CG16752-PC
    CG16752-PD
    SP receptor
    SPR-PA
    SPR-PB
    SPR-PC
    SPR-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5446656..5494012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382034.1 → NP_001368972.1  Sex peptide receptor, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EEN9
      Conserved Domains (1) summary
      cd14978
      Location:90 → 400
      7tmA_FMRFamide_R-like; FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_131997.2 → NP_572225.1  Sex peptide receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572225.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SWR3, Q9W4B9
      Related
      FBpp0070744
      Conserved Domains (2) summary
      pfam00001
      Location:107 → 389
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:97 → 404
      7tm_4; Olfactory receptor

    3. NM_001297964.1 → NP_001284893.1  Sex peptide receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284893.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SWR3, Q9W4B9
      Conserved Domains (2) summary
      pfam00001
      Location:107 → 389
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:97 → 404
      7tm_4; Olfactory receptor

    4. NM_001297963.1 → NP_001284892.1  Sex peptide receptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SWR3, Q9W4B9
      Conserved Domains (2) summary
      pfam00001
      Location:107 → 389
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:97 → 404
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6H2EEN9 A0A6H2EEN9
    Q8SWR3.1 Q8SWR3

    Gene LinkOut

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