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    OtopLc Otopetrin-like c [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 7354434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OtopLcprovided by FlyBase
    Official Full Name
    Otopetrin-like cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259150
    Locus tag
    Dmel_CG42265
    See related
    AllianceGenome:FB:FBgn0259150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15776; CG15777; CG17758; CG42265; Dmel\CG42265; dmOTOPLc; dm_OtopLc; otoplc; OtopLC
    Old locus tag
    Dmel_CG15776; Dmel_CG15777; Dmel_CG17758
    Summary
    Enables proton channel activity. Involved in proton transmembrane transport. Predicted to be active in membrane. Is expressed in adult head. Orthologous to human OTOP2 (otopetrin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See OtopLc in Genome Data Viewer
    Location:
    5A9-5A10; 1-12 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5650567..5662861, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5544600..5556894, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene POP1 ribonuclease P/MRP subunit Neighboring gene Otopetrin-like a Neighboring gene antisense RNA:CR45520 Neighboring gene Sirtuin 4 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and cellular basis of acid taste sensation in Drosophila. Mi T, et al. Nat Commun, 2021 Jun 17. PMID 34140480, Free PMC Article
    2. Requirement for an Otopetrin-like protein for acid taste in Drosophila. Ganguly A, et al. Proc Natl Acad Sci U S A, 2021 Dec 21. PMID 34911758, Free PMC Article
    3. Female site-specific transposase-induced recombination: a high-efficiency method for fine mapping mutations on the X chromosome in Drosophila. Marcus JM. Genetics, 2003 Feb. PMID 12618398, Free PMC Article
    4. Identification of novel candidate genes leading to sex differentiation in primordial germ cells of Drosophila. Ota R, et al. Gene Expr Patterns, 2023 Jun. PMID 37142099
    5. An evolutionarily conserved gene family encodes proton-selective ion channels. Tu YH, et al. Science, 2018 Mar 2. PMID 29371428, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables proton channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Otopetrin-like c
    Names
    CG42265-PD
    CG42265-PE
    CG42265-PF
    OtopLc-PD
    OtopLc-PE
    OtopLc-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5650567..5662861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144689.3 → NP_001138161.2  Otopetrin-like c, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138161.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0X0
      Conserved Domains (1) summary
      pfam03189
      Location:1015 → 1434
      Otopetrin; Otopetrin

    2. NM_001144688.3 → NP_001138160.2  Otopetrin-like c, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138160.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0S0X6R3, B7Z0W9, B7Z0X0
      Conserved Domains (2) summary
      PRK13875
      Location:457 → 587
      PRK13875; conjugal transfer protein TrbL; Provisional
      pfam03189
      Location:1015 → 1434
      Otopetrin; Otopetrin

    3. NM_001316646.1 → NP_001303575.1  Otopetrin-like c, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0X6R3
      Conserved Domains (1) summary
      pfam03189
      Location:1015 → 1434
      Otopetrin; Otopetrin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0W9.2 B7Z0W9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials