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    Dok Downstream of kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31667, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dokprovided by FlyBase
    Official Full Name
    Downstream of kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029944
    Locus tag
    Dmel_CG2079
    See related
    AllianceGenome:FB:FBgn0029944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2079; Ddok; Dmel\CG2079; dok; l(1)G0331
    Summary
    Involved in dorsal closure, elongation of leading edge cells; imaginal disc morphogenesis; and stress-activated protein kinase signaling cascade. Located in cell cortex. Is expressed in several structures, including amnioproctodeal invagination; embryonic cortex; embryonic hindgut; embryonic/larval midgut primordium; and epithelium. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human DOK1 (docking protein 1); DOK2 (docking protein 2); and DOK3 (docking protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dok in Genome Data Viewer
    Location:
    7B1-7B1; 1-20 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7324214..7328806)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7218247..7222839)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44357 Neighboring gene uncharacterized protein Neighboring gene brinker Neighboring gene Autophagy-related 5 Neighboring gene uncharacterized protein Neighboring gene Acyl-CoA synthetase family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Dok is required for embryonic dorsal closure. Biswas R, et al. Development, 2006 Jan. PMID 16339186
    2. Dynein light chain-dependent dimerization of Egalitarian is essential for maintaining oocyte fate in Drosophila. Neiswender H, et al. Dev Biol, 2021 Oct. PMID 34181915, Free PMC Article
    3. The Egalitarian binding partners Dynein light chain and Bicaudal-D act sequentially to link mRNA to the Dynein motor. Goldman CH, et al. Development, 2019 Aug 9. PMID 31391195, Free PMC Article
    4. Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway. Ríos-Barrera LD, et al. Genesis, 2013 Mar. PMID 23109363
    5. Expression profiling of prospero in the Drosophila larval chemosensory organ: Between growth and outgrowth. Guenin L, et al. BMC Genomics, 2010 Jan 19. PMID 20085633, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure, elongation of leading edge cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc fusion, thorax closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stress-activated protein kinase signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    downstream of kinase
    Names
    CG2079-PA
    Dok-PA
    lethal (1) G0331

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7324214..7328806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132163.4 → NP_572391.1  downstream of kinase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572391.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3R6
      Related
      FBpp0071008
      Conserved Domains (3) summary
      smart00233
      Location:6 → 110
      PH; Pleckstrin homology domain
      pfam00169
      Location:6 → 107
      PH; PH domain
      cl17171
      Location:138 → 232
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3R6 Q9W3R6

    Gene LinkOut

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