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    rumpel rumpel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rumpelprovided by FlyBase
    Official Full Name
    rumpelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029950
    Locus tag
    Dmel_CG9657
    See related
    AllianceGenome:FB:FBgn0029950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg9657; CG9657; Dmel\CG9657; dSLC5A9
    Summary
    Enables solute:sodium symporter activity. Involved in transmembrane transport. Is active in plasma membrane. Is expressed in adult head; adult main segment of Malpighian tubule; ensheathing glial cell; larval ventral nerve cord; and lateral cord neurons. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rumpel in Genome Data Viewer
    Location:
    7B2-7B2; 1-20 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7418594..7422142)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7312627..7316175)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Social reprogramming in ants induces longevity-associated glia remodeling. Sheng L, et al. Sci Adv, 2020 Aug. PMID 32875108, Free PMC Article
    2. Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruli. Wu B, et al. Proc Natl Acad Sci U S A, 2017 Jul 18. PMID 28674010, Free PMC Article
    3. Developmental neural activity requires neuron-astrocyte interactions. Bajar BT, et al. Dev Neurobiol, 2022 Apr. PMID 35225404, Free PMC Article
    4. The glia of the adult Drosophila nervous system. Kremer MC, et al. Glia, 2017 Apr. PMID 28133822, Free PMC Article
    5. Redundant functions of the SLC5A transporters Rumpel, Bumpel, and Kumpel in ensheathing glial cells. Yildirim K, et al. Biol Open, 2022 Jan 15. PMID 34897385, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables solute:sodium symporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rumpel
    Names
    CG9657-PA
    CG9657-PB
    rumpel-PA
    rumpel-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7418594..7422142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298054.1 → NP_001284983.1  rumpel, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284983.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSS3, Q9W3R0
      Conserved Domains (1) summary
      cd11492
      Location:16 → 554
      SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain

    2. NM_132169.3 → NP_572397.1  rumpel, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572397.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSS3, Q9W3R0
      Related
      FBpp0071015
      Conserved Domains (1) summary
      cd11492
      Location:16 → 554
      SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSS3 Q8MSS3
    Q9W3R0 Q9W3R0

    Gene LinkOut

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