U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ir8a Ionotropic receptor 8a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31867, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ir8aprovided by FlyBase
    Official Full Name
    Ionotropic receptor 8aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052704
    Locus tag
    Dmel_CG32704
    See related
    AllianceGenome:FB:FBgn0052704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    8a; CG12122; CG12666; CG32704; CT7438; DmelIR8a; Dmel\CG32704; IR8a
    Summary
    Enables coreceptor activity and signaling receptor binding activity. Contributes to extracellular phenylacetaldehyde-gated monoatomic ion channel activity and olfactory receptor activity. Involved in several processes, including cellular response to acetate; detection of chemical stimulus involved in sensory perception of smell; and olfactory behavior. Located in dendrite membrane and sensory dendrite. Part of receptor complex. Is expressed in adult antennal lobe glomerulus; adult antennal olfactory receptor neurons; adult antennal sense organ; and antenna. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 18. Orthologous to human GRID1 (glutamate ionotropic receptor delta type subunit 1) and GRID2 (glutamate ionotropic receptor delta type subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ir8a in Genome Data Viewer
    Location:
    8D2-8D2; 1-27 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9232726..9236585, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9126759..9130618, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 8a Neighboring gene uncharacterized protein Neighboring gene mir-4916 stem loop Neighboring gene multi sex combs Neighboring gene La related protein 7 Neighboring gene almondex

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Vibrational Detection of Odorant Functional Groups by Drosophila melanogaster. Maniati K, et al. eNeuro, 2017 Sep-Oct. PMID 29094064, Free PMC Article
    2. Pheromonal Cues Deposited by Mated Females Convey Social Information about Egg-Laying Sites in Drosophila Melanogaster. Duménil C, et al. J Chem Ecol, 2016 Mar. PMID 26994611, Free PMC Article
    3. Heterologous investigation of metabotropic and ionotropic odorant receptors in ab3A neurons of Drosophila melanogaster. Pettersson JH, et al. Front Mol Biosci, 2023. PMID 38344364, Free PMC Article
    4. Odor-identity dependent motor programs underlie behavioral responses to odors. Jung SH, et al. Elife, 2015 Oct 6. PMID 26439011, Free PMC Article
    5. Ir76b is a Co-receptor for Amine Responses in Drosophila Olfactory Neurons. Vulpe A, et al. Front Cell Neurosci, 2021. PMID 34867202, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IR8a is a subunit that forms a functional olfactory receptor with IR64a in vivo to mediate odor detection
      Title: Ionotropic glutamate receptors IR64a and IR8a form a functional odorant receptor complex in vivo in Drosophila.
    2. IR8a and IR25a are essential for odor-evoked electrophysiological responses in multiple distinct neuron classes.
      Title: Functional architecture of olfactory ionotropic glutamate receptors.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables coreceptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to extracellular ligand-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to extracellular phenylacetaldehyde-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    contributes_to olfactory receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to acetate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to acetate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to chlorate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sensory dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ionotropic receptor 8a
    Names
    CG32704-PA
    Ir8a-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9232726..9236585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167185.1 → NP_727328.1  ionotropic receptor 8a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727328.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9NA95, Q9W365
      Related
      FBpp0071268, FBtr0071333
      Conserved Domains (2) summary
      cd13717
      Location:383 → 786
      PBP2_iGluR_putative; The ligand-binding domain of putative ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:520 → 818
      Lig_chan; Ligand-gated ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W365 Q9W365

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous