Ptpmeg2 Protein tyrosine phosphatase Meg2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ptpmeg2provided by FlyBase
Official Full Name: Protein tyrosine phosphatase Meg2provided by FlyBase
Primary source: FLYBASE:FBgn0028341
Locus tag: Dmel_CG32697
See related: AllianceGenome:FB:FBgn0028341
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3101; CG3102; CG32697; dMeg2; Dmel\CG32697; l(1)G0232; L(1)G0232; lG0232; MEG2; PTP-Meg2
Summary: Enables non-membrane spanning protein tyrosine phosphatase activity. Involved in border follicle cell migration and positive regulation of macroautophagy. Located in cytosol. Is expressed in adult brain and adult head. Orthologous to human PTPN9 (protein tyrosine phosphatase non-receptor type 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 8F2-8F6; 1-29 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (9626294..9659145, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (9520327..9553178, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables non-membrane spanning protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: protein tyrosine phosphatase Meg2

Names: CG32697-PA; CG32697-PB; CG32697-PC; CG32697-PD; CG32697-PE; CG32697-PF; CG32697-PG; CG32697-PH; CG32697-PI; Ptpmeg2-PA; Ptpmeg2-PB; Ptpmeg2-PC; Ptpmeg2-PD; Ptpmeg2-PE; Ptpmeg2-PF; Ptpmeg2-PG; Ptpmeg2-PH; Ptpmeg2-PI; lethal (1) G0232

NP_001014728.1

EC 3.1.3.-

EC 3.1.3.48

NP_001014729.1

EC 3.1.3.-

EC 3.1.3.48

NP_001188573.1

EC 3.1.3.-

EC 3.1.3.48

NP_001188574.1

EC 3.1.3.-

EC 3.1.3.48

NP_001259386.1

EC 3.1.3.-

EC 3.1.3.48

NP_572576.1

EC 3.1.3.-

EC 3.1.3.48

NP_727356.1

EC 3.1.3.-

EC 3.1.3.48

NP_727357.1

EC 3.1.3.-

EC 3.1.3.48

NP_727358.1

EC 3.1.3.-

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

9626294..9659145 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167199.4 → NP_727358.1 protein tyrosine phosphatase Meg2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727358.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IRM6

Related

FBpp0099557

Conserved Domains (2) summary

cd00047
Location:230 → 474

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:228 → 474

Y_phosphatase; Protein-tyrosine phosphatase
NM_001014728.4 → NP_001014728.1 protein tyrosine phosphatase Meg2, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014728.1

Status: REVIEWED

UniProtKB/TrEMBL

Q59E68

Conserved Domains (3) summary

cd00047
Location:329 → 573

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00170
Location:1 → 84

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

pfam00102
Location:327 → 573

Y_phosphatase; Protein-tyrosine phosphatase
NM_001201644.3 → NP_001188573.1 protein tyrosine phosphatase Meg2, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188573.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MS42

Conserved Domains (4) summary

smart01100
Location:77 → 107

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

cd00047
Location:522 → 766

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00170
Location:133 → 277

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

pfam00102
Location:520 → 766

Y_phosphatase; Protein-tyrosine phosphatase
NM_167197.3 → NP_727356.1 protein tyrosine phosphatase Meg2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727356.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IRM7

Related

FBpp0099556

Conserved Domains (4) summary

smart01100
Location:84 → 114

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

cd00047
Location:529 → 773

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00170
Location:140 → 284

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

pfam00102
Location:527 → 773

Y_phosphatase; Protein-tyrosine phosphatase
NM_132348.3 → NP_572576.1 protein tyrosine phosphatase Meg2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572576.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960Z9, Q9W323

Related

FBpp0099554

Conserved Domains (4) summary

smart01100
Location:114 → 144

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

cd00047
Location:559 → 803

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00170
Location:170 → 314

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

pfam00102
Location:557 → 803

Y_phosphatase; Protein-tyrosine phosphatase
NM_167198.2 → NP_727357.1 protein tyrosine phosphatase Meg2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727357.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W324

Related

FBpp0099555

Conserved Domains (4) summary

smart01100
Location:89 → 119

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

cd00047
Location:534 → 778

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00170
Location:145 → 289

SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...

pfam00102
Location:532 → 778

Y_phosphatase; Protein-tyrosine phosphatase
NM_001272457.1 → NP_001259386.1 protein tyrosine phosphatase Meg2, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259386.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IRM6

Conserved Domains (2) summary

cd00047
Location:230 → 474

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:228 → 474

Y_phosphatase; Protein-tyrosine phosphatase
NM_001014729.3 → NP_001014729.1 protein tyrosine phosphatase Meg2, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014729.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IRM6

Conserved Domains (2) summary

cd00047
Location:230 → 474

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:228 → 474

Y_phosphatase; Protein-tyrosine phosphatase
NM_001201645.2 → NP_001188574.1 protein tyrosine phosphatase Meg2, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188574.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IRM6

Conserved Domains (2) summary

cd00047
Location:230 → 474

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:228 → 474

Y_phosphatase; Protein-tyrosine phosphatase