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    dpr8 defective proboscis extension response 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32387, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpr8provided by FlyBase
    Official Full Name
    defective proboscis extension response 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0052600
    Locus tag
    Dmel_CG32600
    See related
    AllianceGenome:FB:FBgn0052600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11477; CG14415; CG32600; CG5291; CT16867; Dmel\CG32600; dpr 8; Dpr-8; Dpr8
    Summary
    Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dpr8 in Genome Data Viewer
    Location:
    12E8-12E10; 1-48 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14322226..14462351)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14216259..14356384)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nascent-associated complex beta-subunit-like, testis 2 Neighboring gene Nascent-associated complex beta-subunit-like, testis 6 Neighboring gene Nascent-associated complex beta-subunit-like, testis 3 Neighboring gene Nascent-associated complex beta-subunit-like, testis 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila. Ramírez F, et al. Mol Cell, 2015 Oct 1. PMID 26431028, Free PMC Article
    2. Population genetic evidence for cold adaptation in European Drosophila melanogaster populations. Božičević V, et al. Mol Ecol, 2016 Mar. PMID 26558479
    3. The dosage compensation complex shapes the conformation of the X chromosome in Drosophila. Grimaud C, et al. Genes Dev, 2009 Nov 1. PMID 19884256, Free PMC Article
    4. Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons. Bornstein B, et al. EMBO J, 2021 Jun 15. PMID 33847376, Free PMC Article
    5. Classifying Protein-Protein Binding Affinity with Free-Energy Calculations and Machine Learning Approaches. Goulard Coderc de Lacam E, et al. J Chem Inf Model, 2024 Feb 12. PMID 38272021

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in sensory perception of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    defective proboscis extension response 8
    Names
    CG32600-PA
    CG32600-PB
    dpr8-PA
    dpr8-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14322226..14462351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167408.2 → NP_727781.1  defective proboscis extension response 8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727781.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SR2, Q9VY33
      Related
      FBpp0073730
      Conserved Domains (3) summary
      smart00410
      Location:153 → 238
      IG_like; Immunoglobulin like
      pfam00047
      Location:153 → 232
      ig; Immunoglobulin domain
      pfam07686
      Location:52 → 143
      V-set; Immunoglobulin V-set domain

    2. NM_001298310.1 → NP_001285239.1  defective proboscis extension response 8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285239.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SR2, Q9VY33
      Conserved Domains (3) summary
      smart00410
      Location:153 → 238
      IG_like; Immunoglobulin like
      pfam00047
      Location:153 → 232
      ig; Immunoglobulin domain
      pfam07686
      Location:52 → 143
      V-set; Immunoglobulin V-set domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95T89 Q95T89
    Q9VY33 Q9VY33

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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