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    nmdyn-D6 nmdyn-D6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32396, updated on 9-Dec-2024

    Summary

    Official Symbol
    nmdyn-D6provided by FlyBase
    Official Full Name
    nmdyn-D6provided by FlyBase
    Primary source
    FLYBASE:FBgn0030573
    Locus tag
    Dmel_CG5310
    See related
    AllianceGenome:FB:FBgn0030573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5310; Dmel\CG5310
    Summary
    Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in cilium movement; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and nucleoside triphosphate biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in cilium. Orthologous to human NME6 (NME/NM23 nucleoside diphosphate kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See nmdyn-D6 in Genome Data Viewer
    Location:
    12F1-12F1; 1-49 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14583677..14584616)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14477710..14478649)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45521 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene sobremesa Neighboring gene Netrin-A

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleoside diphosphate kinase activity  
    enables nucleoside diphosphate kinase activity  
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process  
    involved_in GTP biosynthetic process  
    involved_in UTP biosynthetic process  
    involved_in cilium movement  
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  
    involved_in nucleoside triphosphate biosynthetic process  
    Component Evidence Code Pubs
    is_active_in cilium  
    located_in mitochondrial matrix  

    General protein information

    Preferred Names
    nmdyn-D6
    Names
    CG5310-PA
    nmdyn-D6-PA
    NP_572965.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14583677..14584616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132737.2 → NP_572965.1  nmdyn-D6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572965.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QG0, Q9N6S7, Q9VY27
      Related
      FBpp0073750
      Conserved Domains (2) summary
      smart00562
      Location:2 → 138
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04414
      Location:2 → 135
      NDPk6; Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has ...
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