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    disco-r disco-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 64875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    disco-rprovided by FlyBase
    Official Full Name
    disco-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0285879
    Locus tag
    Dmel_CG32577
    See related
    AllianceGenome:FB:FBgn0285879
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bae; CG32577; CG9219; CG9223; Dmel\CG32577
    Summary
    Involved in delamination; epithelial to mesenchymal transition; and imaginal disc-derived wing expansion. Predicted to be active in nucleus. Is expressed in several structures, including circular visceral muscle fiber; clypeo-labral primordium; imaginal disc; larval foregut atrium; and ventral epidermis primordium. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 16. Orthologous to human BNC1 (basonuclin zinc finger protein 1) and BNC2 (basonuclin zinc finger protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See disco-r in Genome Data Viewer
    Location:
    14B1-14B1; 1-53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16118067..16148977, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16012100..16043010, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Transducer of ERBB2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46211 Neighboring gene mir-985 stem loop Neighboring gene disconnected

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Basonuclins and disco: Orthologous zinc finger proteins essential for development in vertebrates and arthropods. Vanhoutteghem A, et al. Biochimie, 2011 Feb. PMID 20870008
    2. Bursicon signaling mutations separate the epithelial-mesenchymal transition from programmed cell death during Drosophila melanogaster wing maturation. Natzle JE, et al. Genetics, 2008 Oct. PMID 18780731, Free PMC Article
    3. Chromophore-assisted laser inactivation of patched protein switches cell fate in the larval visual system of Drosophila. Schmucker D, et al. Proc Natl Acad Sci U S A, 1994 Mar 29. PMID 8146172, Free PMC Article
    4. The appendage role of insect disco genes and possible implications on the evolution of the maggot larval form. Patel M, et al. Dev Biol, 2007 Sep 1. PMID 17643406
    5. Genetic dissection of intraspecific variation in a male-specific sexual trait in Drosophila melanogaster. Cloud-Richardson KM, et al. Heredity (Edinb), 2016 Dec. PMID 27530909, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in delamination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing expansion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disco-related
    Names
    CG32577-PA
    CG32577-PB
    CG32577-PC
    CG32577-PD
    baetone
    batone
    disco-r-PA
    disco-r-PB
    disco-r-PC
    disco-r-PD
    disconnected-related
    discorelated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16118067..16148977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272670.2 → NP_001259599.1  disco-related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q32KD0, Q9VXJ5, Q9VXJ6
      Conserved Domains (1) summary
      sd00019
      Location:1028 → 1053
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001272669.1 → NP_001259598.1  disco-related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259598.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q32KD0, Q9VXJ5, Q9VXJ6
      Conserved Domains (1) summary
      sd00019
      Location:1028 → 1053
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_167487.3 → NP_727938.1  disco-related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727938.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q32KD0, Q9VXJ5, Q9VXJ6
      Related
      FBpp0074029
      Conserved Domains (1) summary
      sd00019
      Location:1028 → 1053
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001272671.1 → NP_001259600.1  disco-related, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q32KD0, Q9VXJ5, Q9VXJ6
      Conserved Domains (1) summary
      sd00019
      Location:1028 → 1053
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GSZ5 Q9GSZ5
    Q9VXJ5 Q9VXJ5

    Gene LinkOut

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