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    CG12531 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32986, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12531provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031064
    Locus tag
    Dmel_CG12531
    See related
    AllianceGenome:FB:FBgn0031064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12531
    Summary
    Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in retinitis pigmentosa 68. Orthologous to human SLC7A14 (solute carrier family 7 member 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12531 in Genome Data Viewer
    Location:
    18E3-18E4; 1-64 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19718923..19730199)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19612956..19624232)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene meso18E Neighboring gene long non-coding RNA:CR44889 Neighboring gene Adaptor Protein complex 1/2, beta subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolite transport across the mammalian and insect brain diffusion barriers. Weiler A, et al. Neurobiol Dis, 2017 Nov. PMID 28237316
    2. A post-ingestive amino acid sensor promotes food consumption in Drosophila. Yang Z, et al. Cell Res, 2018 Oct. PMID 30209352, Free PMC Article
    3. Drosophila melanogaster: A Valuable Genetic Model Organism to Elucidate the Biology of Retinitis Pigmentosa. Lehmann M, et al. Methods Mol Biol, 2019. PMID 30324448
    4. A screen for neurotransmitter transporters expressed in the visual system of Drosophila melanogaster identifies three novel genes. Romero-Calderón R, et al. Dev Neurobiol, 2007 Apr. PMID 17443808
    5. Computation-based discovery of related transcriptional regulatory modules and motifs using an experimentally validated combinatorial model. Halfon MS, et al. Genome Res, 2002 Jul. PMID 12097338, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12531-PA
    CG12531-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19718923..19730199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134506.3 → NP_608350.2  uncharacterized protein Dmel_CG12531, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608350.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H832, Q9VWD3
      Conserved Domains (2) summary
      TIGR00906
      Location:52 → 679
      2A0303; cationic amino acid transport permease
      pfam13906
      Location:629 → 679
      AA_permease_C; C-terminus of AA_permease

    2. NM_001272799.1 → NP_001259728.1  uncharacterized protein Dmel_CG12531, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259728.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H832, M9PHM0
      Conserved Domains (2) summary
      TIGR00906
      Location:52 → 679
      2A0303; cationic amino acid transport permease
      pfam13906
      Location:629 → 679
      AA_permease_C; C-terminus of AA_permease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHM0 M9PHM0
    Q9VWD3 Q9VWD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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