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    SkpE SKP1-related E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32997, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SkpEprovided by FlyBase
    Official Full Name
    SKP1-related Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031074
    Locus tag
    Dmel_CG11942
    See related
    AllianceGenome:FB:FBgn0031074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11942; Dmel\CG11942; Skp; skpE
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SkpE in Genome Data Viewer
    Location:
    18F2-18F2; 1-64 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19823368..19824080, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19717401..19718113, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene SKP1-related D Neighboring gene SKP1-related C Neighboring gene pico Neighboring gene Nucleoporin 205kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation. Murphy TD. J Cell Sci, 2003 Jun 1. PMID 12730292
    2. Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila. Chen S, et al. Cell Rep, 2012 Feb 23. PMID 22832161, Free PMC Article
    3. A set of structural features defines the cis-regulatory modules of antenna-expressed genes in Drosophila melanogaster. López Y, et al. PLoS One, 2014. PMID 25153327, Free PMC Article
    4. Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development. Roberts DM, et al. PLoS One, 2012. PMID 22359584, Free PMC Article
    5. The E3 ligase Poe promotes Pericentrin degradation. Galletta BJ, et al. Mol Biol Cell, 2023 Aug 1. PMID 37342879, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SKP1-related E
    Names
    CG11942-PA
    SkpE-PA
    skpE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19823368..19824080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134515.2 → NP_608359.1  SKP1-related E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608359.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5IF81, Q9VWC3
      Related
      FBpp0074575
      Conserved Domains (3) summary
      COG5201
      Location:3 → 156
      SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
      pfam01466
      Location:88 → 156
      Skp1; Skp1 family, dimerization domain
      cl02518
      Location:6 → 114
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWC3 Q9VWC3

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