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    Ir21a Ionotropic receptor 21a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33157, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ir21aprovided by FlyBase
    Official Full Name
    Ionotropic receptor 21aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031209
    Locus tag
    Dmel_CG2657
    See related
    AllianceGenome:FB:FBgn0031209
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    21a; CG2657; CT8983; DmelIR21a; Dmel\CG2657; ir21a; IR21a
    Summary
    Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in detection of chemical stimulus involved in sensory perception. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Is expressed in adult sense organ; dorsal organ sensory neurons; ganglia; and sensory neurons. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ir21a in Genome Data Viewer
    Location:
    21A4-21B1; 2-0.5 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21823..25155, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21823..25155, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene lethal (2) giant larvae Neighboring gene antisense RNA:CR43609 Neighboring gene Chitin deacetylase-like 5 Neighboring gene long non-coding RNA:CR46254 Neighboring gene long non-coding RNA:CR45339

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional labeling of individualized postsynaptic neurons using optogenetics and trans-Tango in Drosophila (FLIPSOT). Castaneda AN, et al. PLoS Genet, 2024 Mar. PMID 38483970, Free PMC Article
    2. Connectomics Analysis Reveals First-, Second-, and Third-Order Thermosensory and Hygrosensory Neurons in the Adult Drosophila Brain. Marin EC, et al. Curr Biol, 2020 Aug 17. PMID 32619476, Free PMC Article
    3. Ionotropic Receptor-dependent cool cells control the transition of temperature preference in Drosophila larvae. Tyrrell JJ, et al. PLoS Genet, 2021 Apr. PMID 33826603, Free PMC Article
    4. Synchronous and opponent thermosensors use flexible cross-inhibition to orchestrate thermal homeostasis. Hernandez-Nunez L, et al. Sci Adv, 2021 Aug. PMID 34452914, Free PMC Article
    5. Ionotropic Receptors Specify the Morphogenesis of Phasic Sensors Controlling Rapid Thermal Preference in Drosophila. Budelli G, et al. Neuron, 2019 Feb 20. PMID 30654923, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus involved in sensory perception IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ionotropic receptor 21a
    Names
    CG2657-PB
    Ir21a-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21823..25155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103573.2 → NP_001097043.1  ionotropic receptor 21a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097043.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VPI2
      Conserved Domains (2) summary
      pfam00060
      Location:407 → 662
      Lig_chan; Ligand-gated ion channel
      cl21456
      Location:289 → 583
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPI2.2 Q9VPI2

    Gene LinkOut

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