BBS8 Bardet-Biedl syndrome 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: BBS8provided by FlyBase
Official Full Name: Bardet-Biedl syndrome 8provided by FlyBase
Primary source: FLYBASE:FBgn0031255
Locus tag: Dmel_CG13691
See related: AllianceGenome:FB:FBgn0031255
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BBS2; CG13691; Dmel\CG13691
Summary: Involved in cilium assembly. Predicted to be located in cilium. Predicted to be part of BBSome. Predicted to be active in ciliary basal body and non-motile cilium. Is expressed in chordotonal neurons; eo neurons; and larval antenno-maxillary sensory complex. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (422873..425321)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (422873..425321)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in cilium assembly	ISM Inferred from Sequence Model more info	PubMed
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of BBSome	IBA Inferred from Biological aspect of Ancestor more info
part_of BBSome	IEA Inferred from Electronic Annotation more info
part_of BBSome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IC Inferred by Curator more info	PubMed
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info

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