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    Tfb4 Transcription factor B4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33294, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tfb4provided by FlyBase
    Official Full Name
    Transcription factor B4provided by FlyBase
    Primary source
    FLYBASE:FBgn0031309
    Locus tag
    Dmel_CG5041
    See related
    AllianceGenome:FB:FBgn0031309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5041; Dmel\CG5041; Dmp34; p34; TFB4
    Summary
    Predicted to be involved in nucleotide-excision repair; response to UV; and transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Is expressed in organism. Orthologous to human GTF2H3 (general transcription factor IIH subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tfb4 in Genome Data Viewer
    Location:
    21F1-21F1; 2-2 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1149445..1150677, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1149445..1150677, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45717 Neighboring gene Major Facilitator Superfamily Transporter 3 Neighboring gene lethal (2) 10685 Neighboring gene Vacuolar protein sorting 29 Neighboring gene capulet Neighboring gene antisense RNA:CR43767 Neighboring gene Transport and Golgi organization 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila. Villicaña C, et al. J Cell Sci, 2013 Jun 1. PMID 23549790
    2. A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer. Stettler K, et al. Dis Model Mech, 2015 Jan. PMID 25431422, Free PMC Article
    3. p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model. Aguilar-Fuentes J, et al. PLoS Genet, 2008 Nov. PMID 19008953, Free PMC Article
    4. RNA polymerase II 140wimp mutant and mutations in the TFIIH subunit XPB differentially affect homeotic gene expression in Drosophila. Gutiérrez L, et al. Genesis, 2004 Sep. PMID 15354295
    5. mtDNA extramitochondrial replication mediates mitochondrial defect effects. Shan Z, et al. iScience, 2024 Feb 16. PMID 38322987, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in RNA polymerase II promoter clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transcription open complex formation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor B4
    Names
    CG5041-PA
    TFB4 ortholog
    Tfb4-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1149445..1150677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134730.3 → NP_608574.2  transcription factor B4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608574.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZ89, Q9VPX4
      Related
      FBpp0077650
      Conserved Domains (1) summary
      pfam03850
      Location:15 → 276
      Tfb4; Transcription factor Tfb4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZ89 Q8SZ89
    Q9VPX4 Q9VPX4

    Gene LinkOut

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