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    E23 Early gene at 23 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43895, updated on 9-Dec-2024

    Summary

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    Official Symbol
    E23provided by FlyBase
    Official Full Name
    Early gene at 23provided by FlyBase
    Primary source
    FLYBASE:FBgn0020445
    Locus tag
    Dmel_CG3327
    See related
    AllianceGenome:FB:FBgn0020445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15410; CG3327; DmCG3327; Dmel\CG3327; e23
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in regulation of circadian rhythm. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See E23 in Genome Data Viewer
    Location:
    23E4-23E5; 2-9 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3334875..3354829, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3334875..3354829, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene GRAM domain containing 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nup98-dependent transcriptional memory is established independently of transcription. Pascual-Garcia P, et al. Elife, 2022 Mar 15. PMID 35289742, Free PMC Article
    2. The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation. Hock T, et al. Proc Natl Acad Sci U S A, 2000 Aug 15. PMID 10931948, Free PMC Article
    3. Powerful, efficient QTL mapping in Drosophila melanogaster using bulked phenotyping and pooled sequencing. Macdonald SJ, et al. Genetics, 2022 Mar 3. PMID 35100395, Free PMC Article
    4. EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes. Kreher J, et al. Nat Commun, 2017 Apr 5. PMID 28378812, Free PMC Article
    5. RNA interference validation of detoxification genes involved in ivermectin tolerance in Drosophila melanogaster. Kim JH, et al. Insect Mol Biol, 2018 Oct. PMID 29888824

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    early gene at 23
    Names
    CG3327-PC
    CG3327-PD
    CG3327-PE
    E23-PC
    E23-PD
    E23-PE
    NP_524648.3
    NP_608768.2
    NP_995622.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3334875..3354829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079909.3 → NP_524648.3  early gene at 23, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524648.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU30, Q9GZ10, Q9VQP3, Q9VQP4
      Conserved Domains (3) summary
      cd03213
      Location:350 → 572
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:363 → 1009
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:744 → 943
      ABC2_membrane; ABC-2 type transporter

    2. NM_205900.2 → NP_995622.1  early gene at 23, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU30, Q9GZ10, Q9VQP3, Q9VQP4
      Conserved Domains (3) summary
      cd03213
      Location:350 → 572
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:363 → 1009
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:744 → 943
      ABC2_membrane; ABC-2 type transporter

    3. NM_134924.2 → NP_608768.2  early gene at 23, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608768.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU30, Q9GZ10, Q9VQP3, Q9VQP4
      Conserved Domains (3) summary
      cd03213
      Location:350 → 572
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      TIGR00955
      Location:363 → 1009
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      pfam01061
      Location:744 → 943
      ABC2_membrane; ABC-2 type transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KU30 Q7KU30
    Q7YU52 Q7YU52
    Q9GZ10 Q9GZ10

    Gene LinkOut

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