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    PGAP5 Post-GPI attachment to proteins 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34116, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGAP5provided by FlyBase
    Official Full Name
    Post-GPI attachment to proteins 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0031997
    Locus tag
    Dmel_CG8455
    See related
    AllianceGenome:FB:FBgn0031997
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8455; Dmel\CG8455
    Summary
    Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in GPI anchor biosynthetic process and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment. Is expressed in adult head and organism. Orthologous to human MPPE1 (metallophosphoesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PGAP5 in Genome Data Viewer
    Location:
    28F1-28F1; 2-30 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8198882..8200652)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8198882..8200652)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44116 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44119 Neighboring gene Sodium/solute co-transporter-like 5A11 Neighboring gene long non-coding RNA:CR44120

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    2. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    3. A Drosophila protein-interaction map centered on cell-cycle regulators. Stanyon CA, et al. Genome Biol, 2004. PMID 15575970, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Post-GPI attachment to proteins 5
    Names
    CG8455-PA
    CG8455-PB
    CG8455-PC
    PGAP5-PA
    PGAP5-PB
    PGAP5-PC
    Post-GPI attachment to proteins 5 ortholog
    NP_001260231.1
    NP_609191.1
    NP_723359.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8198882..8200652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273302.1 → NP_001260231.1  Post-GPI attachment to proteins 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260231.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLR9
      Conserved Domains (2) summary
      cd08165
      Location:48 → 301
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:45 → 279
      Metallophos; Calcineurin-like phosphoesterase

    2. NM_164798.3 → NP_723359.1  Post-GPI attachment to proteins 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723359.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLR9
      Related
      FBpp0079208
      Conserved Domains (2) summary
      cd08165
      Location:48 → 301
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:45 → 279
      Metallophos; Calcineurin-like phosphoesterase

    3. NM_135347.3 → NP_609191.1  Post-GPI attachment to proteins 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9PF55, Q8T3Q1, Q9VLR9
      Related
      FBpp0079209
      Conserved Domains (2) summary
      cd08165
      Location:48 → 301
      MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
      pfam00149
      Location:45 → 279
      Metallophos; Calcineurin-like phosphoesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLR9.4 Q9VLR9

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