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    ath athos [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    athprovided by FlyBase
    Official Full Name
    athosprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032194
    Locus tag
    Dmel_CG4901
    See related
    AllianceGenome:FB:FBgn0032194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg4901; CG4901; Dmel\CG4901
    Summary
    Enables rRNA binding activity. Involved in ribosome biogenesis. Is active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human DHX33 (DEAH-box helicase 33). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ath in Genome Data Viewer
    Location:
    31B1-31B1; 2-40 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10211143..10213721)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10211170..10213721)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44845 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Niemann-Pick type C-1a Neighboring gene Proteasome alpha6 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis. Martin ET, et al. Dev Cell, 2022 Apr 11. PMID 35413237, Free PMC Article
    2. Tracing the origin of the compensasome: evolutionary history of DEAH helicase and MYST acetyltransferase gene families. Sanjuán R, et al. Mol Biol Evol, 2001 Mar. PMID 11230534
    3. Misexpression screen delineates novel genes controlling Drosophila lifespan. Paik D, et al. Mech Ageing Dev, 2012 May. PMID 22366109, Free PMC Article
    4. p53 directs focused genomic responses in Drosophila. Akdemir F, et al. Oncogene, 2007 Aug 9. PMID 17310982
    5. The genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel. Wang JB, et al. PLoS Pathog, 2017 Mar. PMID 28257468, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    athos
    Names
    CG4901-PA
    CG4901-PB
    CG4901-PC
    ath-PA
    ath-PB
    ath-PC
    NP_001334733.1
    NP_001334734.1
    NP_609356.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10211143..10213721
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001347806.1 → NP_001334734.1  athos, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MYY2, Q9VL25

    2. NM_001347805.1 → NP_001334733.1  athos, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MYY2, Q9VL25

    3. NM_135512.4 → NP_609356.2  athos, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609356.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MYY2, Q9VL25
      Related
      FBpp0079537
      Conserved Domains (5) summary
      smart00847
      Location:469 → 554
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:23 → 691
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd00046
      Location:87 → 228
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:280 → 401
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:603 → 688
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VL25.2 Q9VL25

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