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    Reps RALBP1 associated Eps domain containing [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34542, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Repsprovided by FlyBase
    Official Full Name
    RALBP1 associated Eps domain containingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032341
    Locus tag
    Dmel_CG6192
    See related
    AllianceGenome:FB:FBgn0032341
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6192; Dmel\CG6192; REPS
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in endocytosis and endosomal transport. Predicted to be active in cytoplasm and plasma membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to several human genes including REPS1 (RALBP1 associated Eps domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Reps in Genome Data Viewer
    Location:
    32D3-32D3; 2-44 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11100963..11106645, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11100963..11106645, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene WD repeat domain 59 Neighboring gene Ge-1 Neighboring gene lethal (2) giant discs 1 Neighboring gene alpha-L-iduronidase Neighboring gene Gustatory receptor 32a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Polymorphism in the Processing Body Component Ge-1 Controls Resistance to a Naturally Occurring Rhabdovirus in Drosophila. Cao C, et al. PLoS Pathog, 2016 Jan. PMID 26799957, Free PMC Article
    2. A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mirey G, et al. Mol Cell Biol, 2003 Feb. PMID 12529414, Free PMC Article
    3. Drosophila Ge-1 promotes P body formation and oskar mRNA localization. Fan SJ, et al. PLoS One, 2011. PMID 21655181, Free PMC Article
    4. Microarray-based capture of novel expressed cell type-specific transfrags (CoNECT) to annotate tissue-specific transcription in Drosophila melanogaster. Hong X, et al. G3 (Bethesda), 2012 Aug. PMID 22908036, Free PMC Article
    5. Modulation of the activity of a polycomb-group response element in Drosophila by a mutation in the transcriptional activator woc. Noyes A, et al. G3 (Bethesda), 2011 Nov. PMID 22384357, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RALBP1 associated Eps domain containing
    Names
    CG6192-PA
    CG6192-PB
    Reps-PA
    Reps-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11100963..11106645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259046.2 → NP_001245975.1  RALBP1 associated Eps domain containing, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245975.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDL7
      Conserved Domains (2) summary
      smart00027
      Location:262 → 345
      EH; Eps15 homology domain
      cd00052
      Location:270 → 336
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...

    2. NM_135643.4 → NP_609487.2  RALBP1 associated Eps domain containing, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609487.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQS4, Q9VKK0
      Related
      FBpp0079817
      Conserved Domains (2) summary
      smart00027
      Location:262 → 345
      EH; Eps15 homology domain
      cd00052
      Location:270 → 336
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDL7 M9NDL7
    Q8MQS4 Q8MQS4

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