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    fs(2)ltoPP43 female sterile (2) ltoPP43 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fs(2)ltoPP43provided by FlyBase
    Official Full Name
    female sterile (2) ltoPP43provided by FlyBase
    Primary source
    FLYBASE:FBgn0004811
    Locus tag
    Dmel_CG10528
    See related
    AllianceGenome:FB:FBgn0004811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD12957; CG10528; Dmel\CG10528; l(2)38Ac; LD12957
    Summary
    Involved in chorion-containing eggshell formation. Is expressed in organism. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy. Orthologous to human SLC7A6OS (solute carrier family 7 member 6 opposite strand). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fs(2)ltoPP43 in Genome Data Viewer
    Location:
    38A3-38A3; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19792773..19795851, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19792773..19795851, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene brain-specific homeobox Neighboring gene Cd GTPase activating protein-related Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U5 at 38AB a Neighboring gene small nuclear RNA U4 at 38AB Neighboring gene sickie

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Application of the gene search system to screen for longevity genes in Drosophila. Seong KH, et al. Biogerontology, 2001. PMID 11708722
    2. The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster. Toba G, et al. Genetics, 1999 Feb. PMID 9927464, Free PMC Article
    3. Map position and expression of the genes in the 38 region of Drosophila. Butler H, et al. Genetics, 2001 Aug. PMID 11514449, Free PMC Article
    4. Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Schüpbach T, et al. Genetics, 1991 Dec. PMID 1783295, Free PMC Article
    5. Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. Gan Q, et al. Cell Res, 2010 Jul. PMID 20440302, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chorion-containing eggshell formation HMP PubMed 
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    female sterile (2) ltoPP43
    Names
    CG10528-PA
    CG10528-PB
    CG10528-PC
    fs(2)ltoPP43-PA
    fs(2)ltoPP43-PB
    fs(2)ltoPP43-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19792773..19795851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080201.3 → NP_524940.1  female sterile (2) ltoPP43, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDM2, Q9VIR8, Q9VIR9
      Related
      FBpp0080849
      Conserved Domains (1) summary
      pfam08574
      Location:194 → 262
      DUF1762; Protein of unknown function (DUF1762)

    2. NM_176062.2 → NP_788076.1  female sterile (2) ltoPP43, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788076.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDU9, Q86BK4
      Related
      FBpp0080850

    3. NM_001273673.1 → NP_001260602.1  female sterile (2) ltoPP43, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260602.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDU9, M9PG97
      Conserved Domains (1) summary
      pfam08574
      Location:193 → 235
      DUF1762; Protein of unknown function (DUF1762)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PG97 M9PG97
    Q86BK4 Q86BK4
    Q95RS2 Q95RS2
    Q9VIR9 Q9VIR9

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