U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lamp1 Lamp1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35411, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lamp1provided by FlyBase
    Official Full Name
    Lamp1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032949
    Locus tag
    Dmel_CG3305
    See related
    AllianceGenome:FB:FBgn0032949
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3305; dLamp; dLAMP; Dmel\CG3305; Lamp; LAMP; Lamp-1; lamp1; LAMP1
    Summary
    Involved in lipophagy. Located in lipid droplet. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; adult heart; and gut section. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to several human genes including LAMP1 (lysosomal associated membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lamp1 in Genome Data Viewer
    Location:
    39E2-39E2; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21573389..21577103)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21573389..21577103)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene histone H3 Neighboring gene pseudo Neighboring gene no mechanoreceptor potential B

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Lamp1 Deficiency Enhances Sensitivity to α-Synuclein and Oxidative Stress in Drosophila Models of Parkinson Disease. Rahmani Z, et al. Int J Mol Sci, 2022 Oct 28. PMID 36361864, Free PMC Article
    2. Defective axonal transport of endo-lysosomes and dense core vesicles in a Drosophila model of C9-ALS/FTD. Sung H, et al. Traffic, 2022 Sep. PMID 35908282
    3. The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson's disease. Yi S, et al. Neural Regen Res, 2024 May. PMID 37862221, Free PMC Article
    4. A Drosophila model to image phagosome maturation. Shandala T, et al. Cells, 2013 Mar 26. PMID 24709696, Free PMC Article
    5. A genetic system to assess in vivo the functions of histones and histone modifications in higher eukaryotes. Günesdogan U, et al. EMBO Rep, 2010 Oct. PMID 20814422, Free PMC Article

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lamp1 Deficiency Enhances Sensitivity to alpha-Synuclein and Oxidative Stress in Drosophila Models of Parkinson Disease.
      Title: Lamp1 Deficiency Enhances Sensitivity to α-Synuclein and Oxidative Stress in Drosophila Models of Parkinson Disease.
    2. Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila.
      Title: Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila.
    3. Drosophila Rab2 is recruited to late endosomal membranes, where it controls the fusion of LAMP-containing biosynthetic carriers and lysosomes to late endosomes.
      Title: Drosophila Rab2 controls endosome-lysosome fusion and LAMP delivery to late endosomes.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: 21575454-21575549 mobile_element_type = transposon:INE-1{}4196
    • Loc: 21575751-21575817 mobile_element_type = transposon:FB{}4833

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in establishment of protein localization to organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Lamp1
    Names
    CG3305-PA
    Lamp1-PA
    lysosomal-associated membrane protein 1
    lysosome-associated membrane protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21573389..21577103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136267.5 → NP_610111.3  Lamp1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610111.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZP0, Q9V9S0
      Related
      FBpp0085251
      Conserved Domains (1) summary
      pfam01299
      Location:77 → 318
      Lamp; Lysosome-associated membrane glycoprotein (Lamp)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZP0 Q8SZP0
    Q9V9S0 Q9V9S0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous