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    CG1941 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35718, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG1941provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033214
    Locus tag
    Dmel_CG1941
    See related
    AllianceGenome:FB:FBgn0033214
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1941
    Summary
    Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and embryonic/larval midgut. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to several human genes including MOGAT1 (monoacylglycerol O-acyltransferase 1); MOGAT2 (monoacylglycerol O-acyltransferase 2); and MOGAT3 (monoacylglycerol O-acyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1941 in Genome Data Viewer
    Location:
    43E12-43E12; 2-57 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7709873..7711981)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3597378..3599486)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene torso Neighboring gene mir-4909 stem loop Neighboring gene Diacylglycerol O-acyltransferase 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparison of embryonic expression within multigene families using the FlyExpress discovery platform reveals more spatial than temporal divergence. Konikoff CE, et al. Dev Dyn, 2012 Jan. PMID 21960044, Free PMC Article
    2. Thematic review series: Lipid droplet synthesis and metabolism: from yeast to man. Lipid droplet-based storage fat metabolism in Drosophila. Kühnlein RP. J Lipid Res, 2012 Aug. PMID 22566574, Free PMC Article
    3. A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown. Wat LW, et al. PLoS Biol, 2020 Jan. PMID 31961851, Free PMC Article
    4. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Wang W, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30521938
    5. Drosophila model for studying the link between lipid metabolism and development. Thanh MT, et al. Front Biosci (Landmark Ed), 2020 Jan 1. PMID 31585882

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diacylglycerol O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1941-PA
    CG1941-PB
    CG1941-PC
    CG1941-PD
    NP_001286161.1
    NP_001286162.1
    NP_001286163.1
    NP_610317.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7709873..7711981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299233.1 → NP_001286162.1  uncharacterized protein Dmel_CG1941, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286162.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYK2
      Conserved Domains (1) summary
      cl17185
      Location:50 → 340
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    2. NM_001299232.1 → NP_001286161.1  uncharacterized protein Dmel_CG1941, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYK2
      Conserved Domains (1) summary
      cl17185
      Location:50 → 340
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    3. NM_136473.3 → NP_610317.1  uncharacterized protein Dmel_CG1941, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610317.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYK2
      Related
      FBpp0088001
      Conserved Domains (1) summary
      cl17185
      Location:50 → 340
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

    4. NM_001299234.1 → NP_001286163.1  uncharacterized protein Dmel_CG1941, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JYK2
      Conserved Domains (1) summary
      cl17185
      Location:50 → 340
      LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JYK2 Q7JYK2

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