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    GstT2 Glutathione S transferase T2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GstT2provided by FlyBase
    Official Full Name
    Glutathione S transferase T2provided by FlyBase
    Primary source
    FLYBASE:FBgn0050005
    Locus tag
    Dmel_CG30005
    See related
    AllianceGenome:FB:FBgn0050005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12930; CG12930A; CG30005; Dmel\CG30005; DmGSTT2; gstt2; GSTT2
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including GSTT1 (glutathione S-transferase theta 1); GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)); and GSTT2B (glutathione S-transferase theta 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstT2 in Genome Data Viewer
    Location:
    45F6-45F6; 2-61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9607292..9608350)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5494797..5495855)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44285 Neighboring gene antisense RNA:CR44069 Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase T1 Neighboring gene Matrix metalloproteinase 2 Neighboring gene mir-307b stem loop Neighboring gene mir-307a stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction of Omega, Sigma, and Theta glutathione transferases with p38b mitogen-activated protein kinase from the fruit fly, Drosophila melanogaster. Wongtrakul J, et al. J Insect Sci, 2014 May 1. PMID 25373207, Free PMC Article
    2. A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotation. Huet F, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12096187, Free PMC Article
    3. A preliminary characterization of the cytosolic glutathione transferase proteome from Drosophila melanogaster. Saisawang C, et al. Biochem J, 2012 Feb 15. PMID 22082028
    4. Molecular evolution of glutathione S-transferases in the genus Drosophila. Low WY, et al. Genetics, 2007 Nov. PMID 18039872, Free PMC Article
    5. Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae. Ranson H, et al. Biochem J, 2001 Oct 15. PMID 11583575, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase T2
    Names
    CG30005-PA
    GstT2-PA
    NP_724816.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9607292..9608350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165690.4 → NP_724816.3  glutathione S transferase T2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724816.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7X7, H0RNE2
      Conserved Domains (3) summary
      COG0625
      Location:7 → 202
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03050
      Location:5 → 80
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
      cl02776
      Location:93 → 218
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7X7 A1Z7X7

    Gene LinkOut

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