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    SkpB SKP1-related B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36298, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SkpBprovided by FlyBase
    Official Full Name
    SKP1-related Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026176
    Locus tag
    Dmel_CG8881
    See related
    AllianceGenome:FB:FBgn0026176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8881; Dmel\CG8881; dskpB; Skp; skpB
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Used to study candidiasis. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SkpB in Genome Data Viewer
    Location:
    48E2-48E2; 2-66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12139295..12140229, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8026800..8027734, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene jelly belly Neighboring gene uncharacterized protein Neighboring gene SET and MYND domain containing, class 4, member 4 Neighboring gene Organic solute carrier partner 1 Neighboring gene Hen1 methyltransferase Neighboring gene back seat driver

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation. Murphy TD. J Cell Sci, 2003 Jun 1. PMID 12730292
    2. The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. Rogers GC, et al. J Cell Biol, 2009 Jan 26. PMID 19171756, Free PMC Article
    3. Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Mohan M, et al. Genes Dev, 2010 Mar 15. PMID 20203130, Free PMC Article
    4. Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Sathyanarayanan S, et al. Genes Dev, 2008 Jun 1. PMID 18519643, Free PMC Article
    5. dGLYAT modulates Gadd45-mediated JNK activation and cell invasion. Xu M, et al. Cell Div, 2022 Aug 6. PMID 35933447, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SKP1-related B
    Names
    CG8881-PA
    SkpB-PA
    skpB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12139295..12140229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136885.4 → NP_610729.1  SKP1-related B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610729.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KJ69
      Related
      FBpp0087127
      Conserved Domains (3) summary
      smart00512
      Location:1 → 110
      Skp1; Found in Skp1 protein family
      COG5201
      Location:1 → 161
      SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
      pfam01466
      Location:84 → 158
      Skp1; Skp1 family, dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KJ69 Q7KJ69

    Gene LinkOut

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