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    Nepl10 Neprilysin-like 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36366, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl10provided by FlyBase
    Official Full Name
    Neprilysin-like 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0033742
    Locus tag
    Dmel_CG8550
    See related
    AllianceGenome:FB:FBgn0033742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8550; Dmel\CG8550
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl10 in Genome Data Viewer
    Location:
    49A7-49A7; 2-67 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12471915..12474021)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8359420..8361526)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Lachesin Neighboring gene dim gamma-tubulin 5 Neighboring gene uncharacterized protein Neighboring gene Diuretic hormone 44 receptor 2 Neighboring gene uncharacterized protein Neighboring gene fused lobes Neighboring gene stanley-cup

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    2. Drosophila TGIF is essential for developmentally regulated transcription in spermatogenesis. Ayyar S, et al. Development, 2003 Jul. PMID 12756169
    3. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    4. Microarray analysis and organization of circadian gene expression in Drosophila. McDonald MJ, et al. Cell, 2001 Nov 30. PMID 11733057
    5. Reproductive status alters transcriptomic response to infection in female Drosophila melanogaster. Short SM, et al. G3 (Bethesda), 2013 May 20. PMID 23550122, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 10
    Names
    CG8550-PA
    Nepl10-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12471915..12474021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136943.2 → NP_610787.1  Neprilysin-like 10 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610787.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z910, E0R947
      Related
      FBpp0087046
      Conserved Domains (1) summary
      cl14813
      Location:41 → 608
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z910 A1Z910

    Gene LinkOut

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