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    Not11 CCR4-NOT transcription complex subunit 11 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37839, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Not11provided by FlyBase
    Official Full Name
    CCR4-NOT transcription complex subunit 11provided by FlyBase
    Primary source
    FLYBASE:FBgn0034963
    Locus tag
    Dmel_CG13567
    See related
    AllianceGenome:FB:FBgn0034963
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C2orf29; CG13567; Dmel\CG13567; NOT11
    Summary
    Involved in mRNA catabolic process and negative regulation of translation. Part of CCR4-NOT complex. Orthologous to human CNOT11 (CCR4-NOT transcription complex subunit 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Not11 in Genome Data Viewer
    Location:
    60B5-60B5; 2-106 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24036720..24037915, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19924243..19925438, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Chip Neighboring gene MAN1 Neighboring gene Integrator 1 Neighboring gene twinstar Neighboring gene gamma Soluble NSF attachment protein 1 Neighboring gene seizure

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and assembly of the NOT10:11 module of the CCR4-NOT complex. Levdansky Y, et al. Commun Biol, 2023 Jul 17. PMID 37460791, Free PMC Article
    2. In Vitro Reconstitution of the Drosophila melanogaster CCR4-NOT Complex to Assay Deadenylation. Pekovic F, et al. Methods Mol Biol, 2024. PMID 37824062
    3. A conserved domain of Drosophila RNA-binding protein Pumilio interacts with multiple CCR4-NOT deadenylase complex subunits to repress target mRNAs. Haugen RJ, et al. J Biol Chem, 2022 Sep. PMID 35850301, Free PMC Article
    4. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. Bawankar P, et al. RNA Biol, 2013 Feb. PMID 23303381, Free PMC Article
    5. The Drosophila LEM-domain protein MAN1 antagonizes BMP signaling at the neuromuscular junction and the wing crossveins. Wagner N, et al. Dev Biol, 2010 Mar 1. PMID 20036230

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NOT10 and NOT11 form a complex that docks onto the NOT1 scaffold via interactions with NOT11 and the N-terminal NOT1 domain.
      Title: NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 11
    Names
    CG13567-PA
    CG13567-PB
    CG13567-PC
    Not11-PA
    Not11-PB
    Not11-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24036720..24037915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299884.1 → NP_001286813.1  CCR4-NOT transcription complex subunit 11, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1C6
      Conserved Domains (1) summary
      pfam10155
      Location:87 → 211
      DUF2363; Uncharacterized conserved protein (DUF2363)

    2. NM_138030.4 → NP_611874.1  CCR4-NOT transcription complex subunit 11, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611874.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1C6
      Related
      FBpp0072098
      Conserved Domains (1) summary
      pfam10155
      Location:87 → 211
      DUF2363; Uncharacterized conserved protein (DUF2363)

    3. NM_166652.4 → NP_726406.1  CCR4-NOT transcription complex subunit 11, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726406.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MLP8
      Related
      FBpp0072099
      Conserved Domains (1) summary
      pfam10155
      Location:87 → 231
      DUF2363; Uncharacterized conserved protein (DUF2363)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLP8 Q8MLP8
    Q9W1C6 Q9W1C6

    Gene LinkOut

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