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    Setx Senataxin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38904, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Setxprovided by FlyBase
    Official Full Name
    Senataxinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035842
    Locus tag
    Dmel_CG7504
    See related
    AllianceGenome:FB:FBgn0035842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7504; Dmel\CG7504; dSETX
    Summary
    Predicted to enable 5'-3' RNA helicase activity; RNA binding activity; and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be active in nuclear body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and spinocerebellar ataxia with axonal neuropathy 2. Orthologous to human SETX (senataxin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Setx in Genome Data Viewer
    Location:
    66B7-66B8; 3-22 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8131429..8137498, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8124529..8130598, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L36 Neighboring gene Ubiquitin-like activating enzyme 2 Neighboring gene CDP-diacylglycerol synthase Neighboring gene mutagen-sensitive 301 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caspar, an adapter for VAPB and TER94, modulates the progression of ALS8 by regulating IMD/NFκB-mediated glial inflammation in a Drosophila model of human disease. Tendulkar S, et al. Hum Mol Genet, 2022 Aug 25. PMID 35377453, Free PMC Article
    2. dRTEL1 is essential for the maintenance of Drosophila male germline stem cells. Yang Y, et al. PLoS Genet, 2021 Oct. PMID 34644293, Free PMC Article
    3. Drosophila models of amyotrophic lateral sclerosis with defects in RNA metabolism. Zhang K, et al. Brain Res, 2018 Aug 15. PMID 29752901
    4. Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target. Kankel MW, et al. Genetics, 2020 Jul. PMID 32345615, Free PMC Article
    5. Suppressor of sable [Su(s)] and Wdr82 down-regulate RNA from heat-shock-inducible repetitive elements by a mechanism that involves transcription termination. Brewer-Jensen P, et al. RNA, 2016 Jan. PMID 26577379, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-3' RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription termination site sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in termination of RNA polymerase II transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    senataxin
    Names
    CG7504-PB
    CG7504-PC
    Setx-PB
    Setx-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8131429..8137498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139920.3 → NP_648177.1  senataxin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSE1
      Related
      FBpp0271876
      Conserved Domains (6) summary
      COG1716
      Location:10 → 101
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:4 → 96
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13086
      Location:912 → 1169
      AAA_11; AAA domain
      pfam13087
      Location:1176 → 1367
      AAA_12; AAA domain
      pfam13245
      Location:935 → 992
      AAA_19; Part of AAA domain
      cl02079
      Location:1034 → 1088
      YtxH; YtxH-like protein

    2. NM_001144435.2 → NP_001137907.1  senataxin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137907.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0D7
      Conserved Domains (6) summary
      COG1716
      Location:10 → 101
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:4 → 96
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam13086
      Location:1171 → 1428
      AAA_11; AAA domain
      pfam13087
      Location:1435 → 1626
      AAA_12; AAA domain
      pfam13245
      Location:1194 → 1251
      AAA_19; Part of AAA domain
      cl02079
      Location:1293 → 1347
      YtxH; YtxH-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0D7 B7Z0D7
    Q9VSE1 Q9VSE1

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