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    fry furry [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39122, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fryprovided by FlyBase
    Official Full Name
    furryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016081
    Locus tag
    Dmel_CG32045
    See related
    AllianceGenome:FB:FBgn0016081
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14171; CG32045; CG6774; CG6780; Dmel\CG32045; Fry; l(3)02240; RE-B; SS3-7; yeti
    Summary
    Involved in several processes, including neuron differentiation; positive regulation of macromolecule metabolic process; and regulation of cell projection organization. Located in several cellular components, including apical part of cell; cell body; and dendrite. Is expressed in adult head; follicle cell; and spermatozoon. Used to study syndromic intellectual disability. Orthologous to human FRYL (FRY like transcription coactivator) and FRY (FRY microtubule binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fry in Genome Data Viewer
    Location:
    67C3-67C4; 3-31 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9631834..9679103, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9624934..9672203, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 67b Neighboring gene Cyclophilin 40 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene CNMamide Receptor Neighboring gene alpha-Tubulin at 67C Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De novo variants in FRYL are associated with developmental delay, intellectual disability, and dysmorphic features. Pan X, et al. Am J Hum Genet, 2024 Apr 4. PMID 38479391, Free PMC Article
    2. The Drosophila Fry protein interacts with Trc and is highly mobile in vivo. Fang X, et al. BMC Dev Biol, 2010 Apr 20. PMID 20406475, Free PMC Article
    3. Dendritic tiling; new insights from genetics. Zinn K. Neuron, 2004 Oct 14. PMID 15473957
    4. A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation. Horne-Badovinac S, et al. G3 (Bethesda), 2012 Mar. PMID 22413091, Free PMC Article
    5. Role of self-avoidance in neuronal wiring. Kise Y, et al. Curr Opin Neurobiol, 2013 Dec. PMID 24161734

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antennal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite self-avoidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing hair organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule sliding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron projection arborization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-sensory hair organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    furry
    Names
    CG32045-PB
    CG32045-PC
    CG32045-PE
    CG32045-PF
    CG32045-PG
    CG32045-PH
    CG32045-PI
    CG32045-PJ
    fry-PB
    fry-PC
    fry-PE
    fry-PF
    fry-PG
    fry-PH
    fry-PI
    fry-PJ
    suppressor of GMR-sina 3-7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9631834..9679103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168357.3 → NP_729520.1  furry, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729520.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8G4, Q8T9A1, Q9BIR5, Q9GPT8, Q9VT28
      Related
      FBpp0076146
      Conserved Domains (3) summary
      pfam14222
      Location:389 → 923
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2453 → 2705
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1278 → 2050
      MOR2-PAG1_mid; Cell morphogenesis central region

    2. NM_001274710.1 → NP_001261639.1  furry, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261639.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF44
      Conserved Domains (3) summary
      pfam14222
      Location:389 → 923
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2453 → 2705
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1278 → 2050
      MOR2-PAG1_mid; Cell morphogenesis central region

    3. NM_001259771.1 → NP_001246700.1  furry, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246700.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFQ5
      Conserved Domains (3) summary
      pfam14222
      Location:389 → 923
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2453 → 2705
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1278 → 2050
      MOR2-PAG1_mid; Cell morphogenesis central region

    4. NM_168356.2 → NP_729519.2  furry, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729519.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCY4
      Conserved Domains (3) summary
      pfam14222
      Location:389 → 923
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2501 → 2753
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1326 → 2098
      MOR2-PAG1_mid; Cell morphogenesis central region

    5. NM_001259772.1 → NP_001246701.1  furry, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246701.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND72
      Conserved Domains (3) summary
      pfam14222
      Location:389 → 923
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2501 → 2753
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1326 → 2098
      MOR2-PAG1_mid; Cell morphogenesis central region

    6. NM_001274709.1 → NP_001261638.1  furry, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEP1
      Conserved Domains (3) summary
      pfam14222
      Location:389 → 923
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2501 → 2753
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1326 → 2098
      MOR2-PAG1_mid; Cell morphogenesis central region

    7. NM_001274708.1 → NP_001261637.1  furry, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261637.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC07
      Conserved Domains (3) summary
      pfam14222
      Location:384 → 918
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2448 → 2700
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1273 → 2045
      MOR2-PAG1_mid; Cell morphogenesis central region

    8. NM_001259770.1 → NP_001246699.1  furry, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246699.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE70
      Conserved Domains (3) summary
      pfam14222
      Location:384 → 918
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2496 → 2748
      MOR2-PAG1_C; Cell morphogenesis C-terminal
      pfam14228
      Location:1321 → 2093
      MOR2-PAG1_mid; Cell morphogenesis central region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QCY4 E2QCY4
    M9ND72 M9ND72
    M9NE70 M9NE70
    M9NFQ5 M9NFQ5
    M9PC07 M9PC07
    M9PEP1 M9PEP1
    M9PF44 M9PF44
    Q9VT28.2 Q9VT28

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