wnd wallenda [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wndprovided by FlyBase
Official Full Name: wallendaprovided by FlyBase
Primary source: FLYBASE:FBgn0036896
Locus tag: Dmel_CG8789
See related: AllianceGenome:FB:FBgn0036896
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8789; DLK; DLK/ZPK; Dmel\CG8789; MAPKKK; Wallenda; Wnd; Wnd/DLK
Summary: Predicted to enable protein kinase activity. Involved in several processes, including collateral sprouting of injured axon; memory; and regulation of synapse organization. Located in axon and neuromuscular junction. Is expressed in several structures, including adult mushroom body; antennal anlage; antennal primordium; brain; and head epidermis primordium. Orthologous to human MAP3K12 (mitogen-activated protein kinase kinase kinase 12) and MAP3K13 (mitogen-activated protein kinase kinase kinase 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 76B9-76B9; 3-45 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19624406..19635783, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19617506..19628883, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells.
Title: Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells.
Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome.
Title: Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome.
These studies at the Drosophila neuromuscular junction indicate that many synaptic defects in unc-104-null mutants are mediated independently of Unc-104's transport function, via the Wallenda (Wnd)/DLK MAP kinase axonal damage signaling pathway.
Title: Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104.
Here the authors identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as a critical target and effector of cAMP in injured axons.
Title: An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK.
Wallenda/DLK protein levels are temporally downregulated by Tramtrack69 to allow R7 growth cones to become stationary boutons
Title: Wallenda/DLK protein levels are temporally downregulated by Tramtrack69 to allow R7 growth cones to become stationary boutons.
our study in Drosophila has uncovered a novel physiological function for Wnd in modulating cell invasion
Title: Rho1-Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila.
DLK is not essential for dendrite regeneration.
Title: Dendrite injury triggers DLK-independent regeneration.
The dual leucine zipper kinase (DLK) signaling pathway in Drosophila, which consists of Highwire and Wallenda and controls axonal growth, regeneration, and degeneration, is also involved in dendritic growth in vivo.
Title: Bimodal control of dendritic and axonal growth by the dual leucine zipper kinase pathway.
The results of this study indicated that Wnd regulates multiple independent pathways in Drosophila motoneurons and that JIP1 scaffolds a specific downstream cascade required for the organization of presynaptic microtubules during synaptic development.
Title: Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling.
Wnd regulates an adaptive response to injury that allows neurons to cope with axonal stress.
Title: A conditioning lesion protects axons from degeneration via the Wallenda/DLK MAP kinase signaling cascade.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2220 (e-PCR)
- UniSTS:9598

Homology

NCBI Orthologs

mobile_element

Loc: c19629120-19628542 mobile_element_type = transposon:INE-1{}5213

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in collateral sprouting of injured axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IGI Inferred from Genetic Interaction more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sprouting of injured axon	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: wallenda

Names: CG8789-PA; CG8789-PB; CG8789-PC; CG8789-PD; dual leucine zipper kinase; dual leucine zipper-bearing kinase; wnd-PA; wnd-PB; wnd-PC; wnd-PD

NP_001189132.1

EC 2.7.11.25

NP_649137.3

EC 2.7.11.25

NP_788540.1

EC 2.7.11.25

NP_788541.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

19624406..19635783 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176363.3 → NP_788541.1 wallenda, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788541.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VW24

Related

FBpp0074733

Conserved Domains (2) summary

smart00221
Location:161 → 400

STYKc; Protein kinase; unclassified specificity

cd14059
Location:167 → 403

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
NM_140880.3 → NP_649137.3 wallenda, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649137.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9VW24

Related

FBpp0074731

Conserved Domains (2) summary

smart00221
Location:161 → 400

STYKc; Protein kinase; unclassified specificity

cd14059
Location:167 → 403

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
NM_176362.2 → NP_788540.1 wallenda, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788540.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VW24

Related

FBpp0074732

Conserved Domains (2) summary

smart00221
Location:161 → 400

STYKc; Protein kinase; unclassified specificity

cd14059
Location:167 → 403

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
NM_001202203.1 → NP_001189132.1 wallenda, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189132.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DMF6

Conserved Domains (2) summary

smart00221
Location:134 → 373

STYKc; Protein kinase; unclassified specificity

cd14059
Location:140 → 376

STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13