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    sac sterile affecting ciliogenesis [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40568, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sacprovided by FlyBase
    Official Full Name
    sterile affecting ciliogenesisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037254
    Locus tag
    Dmel_CG14651
    See related
    AllianceGenome:FB:FBgn0037254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14651; Dmel\CG14651
    Summary
    Predicted to enable dynein intermediate chain binding activity and dynein light intermediate chain binding activity. Involved in flagellated sperm motility. Located in sperm flagellum. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sac in Genome Data Viewer
    Location:
    82B3-82B3; 3-47.1 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4480812..4484215)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (306534..309937)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43629 Neighboring gene uncharacterized protein Neighboring gene Factor interacting with poly(A) polymerase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impact of cilia-related genes on mitochondrial dynamics during Drosophila spermatogenesis. Bauerly E, et al. Dev Biol, 2022 Feb. PMID 34822845
    2. The Green Valley of Drosophila melanogaster Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control. Messina G, et al. Cells, 2022 Sep 29. PMID 36231024, Free PMC Article
    3. Structure and molecular basis of spermatid elongation in the Drosophila testis. Huang Q, et al. Open Biol, 2023 Nov. PMID 37935354, Free PMC Article
    4. A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth. Laviolette MJ, et al. Genetics, 2005 Jun. PMID 15834148, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sterile affecting ciliogenesis
    Names
    CG14651-PB
    sac-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4480812..4484215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141218.3 → NP_649475.3  sterile affecting ciliogenesis [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649475.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1LZ49, Q9VN30
      Conserved Domains (1) summary
      pfam08393
      Location:904 → 1042
      DHC_N2; Dynein heavy chain, N-terminal region 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VN30 Q9VN30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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