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    CG10280 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10280provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037395
    Locus tag
    Dmel_CG10280
    See related
    AllianceGenome:FB:FBgn0037395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10280
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human ASTL (astacin like metalloendopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10280 in Genome Data Viewer
    Location:
    83D2-83D2; 3-47.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6010573..6011932, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1836295..1837654, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44928 Neighboring gene Rm62 Neighboring gene Cathepsin L3 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Insect Prothoracic Gland as a Model for Steroid Hormone Biosynthesis and Regulation. Ou Q, et al. Cell Rep, 2016 Jun 28. PMID 27320926, Free PMC Article
    2. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
    3. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
    4. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article
    5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10280-PA
    CG10280-PB
    NP_001246942.1
    NP_649607.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6010573..6011932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141350.1 → NP_649607.1  uncharacterized protein Dmel_CG10280, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNK5
      Related
      FBpp0078297, FBtr0078648
      Conserved Domains (2) summary
      cd04280
      Location:145 → 336
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:141 → 338
      Astacin; Astacin (Peptidase family M12A)

    2. NM_001260013.1 → NP_001246942.1  uncharacterized protein Dmel_CG10280, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K600
      Conserved Domains (2) summary
      cd04280
      Location:151 → 342
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:147 → 344
      Astacin; Astacin (Peptidase family M12A)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K600 A0A0B4K600
    Q9VNK5 Q9VNK5

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