U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sgt1 suppressor-of-G2-allele-of-skp1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40982, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sgt1provided by FlyBase
    Official Full Name
    suppressor-of-G2-allele-of-skp1provided by FlyBase
    Primary source
    FLYBASE:FBgn0265101
    Locus tag
    Dmel_CG9617
    See related
    AllianceGenome:FB:FBgn0265101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9617; Dmel\CG9617; DmSgt1; l(3)s2383; Q9VHT3; sgt1
    Summary
    Predicted to enable protein-folding chaperone binding activity and protein-macromolecule adaptor activity. Involved in centrosome cycle; maintenance of neuroblast polarity; and protein stabilization. Located in centrosome; cleavage furrow; and kinetochore. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sgt1 in Genome Data Viewer
    Location:
    84F10-84F10; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8304190..8305274, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4129912..4130996, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L1 Neighboring gene neuronally altered carbohydrate Neighboring gene mir-4918 stem loop Neighboring gene tex Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. p23 and HSP20/alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families. Garcia-Ranea JA, et al. FEBS Lett, 2002 Oct 9. PMID 12372593
    2. Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing. Claudius AK, et al. PLoS Genet, 2014 Apr. PMID 24722212, Free PMC Article
    3. Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system. Gailite I, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324895, Free PMC Article
    4. Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization. Martins T, et al. EMBO J, 2009 Feb 4. PMID 19131964, Free PMC Article
    5. Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts. Andersen RO, et al. Dev Biol, 2012 Mar 1. PMID 22248825, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of neuroblast polarity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    suppressor-of-G2-allele-of-skp1
    Names
    CG9617-PA
    Sgt1-PA
    lethal (3) s2383

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8304190..8305274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141526.4 → NP_649783.2  suppressor-of-G2-allele-of-skp1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649783.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0MKD5, C0MKD9, Q8SY87, Q9VHT3
      Related
      FBpp0081351
      Conserved Domains (2) summary
      cd06466
      Location:6 → 84
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      pfam05002
      Location:97 → 176
      SGS; SGS domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2XYI8 Q2XYI8
    Q8SY87 Q8SY87
    Q9VHT3 Q9VHT3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous