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    St2 Sulfotransferase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41098, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St2provided by FlyBase
    Official Full Name
    Sulfotransferase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037665
    Locus tag
    Dmel_CG16733
    See related
    AllianceGenome:FB:FBgn0037665
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16733; Dmel\CG16733; dmST2; st2
    Summary
    Predicted to enable sulfotransferase activity. Predicted to be involved in sulfation. Predicted to be active in cytoplasm. Is expressed in eye disc anterior to the morphogenetic furrow; wing disc; and wing margin. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital ichthyosis 14; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1C2 (sulfotransferase family 1C member 2) and SULT1C4 (sulfotransferase family 1C member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See St2 in Genome Data Viewer
    Location:
    85D4-85D4; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9251843..9253514)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5077565..5079236)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 15 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, and characterization of cytosolic sulfotransferase isozymes from Drosophila melanogaster. Hattori K, et al. Biosci Biotechnol Biochem, 2008 Feb. PMID 18256476
    2. Expression analysis of a family of developmentally-regulated cytosolic sulfotransferases (SULTs) in Drosophila. Fahmy K, et al. Hereditas, 2013 Jun. PMID 23865965
    3. E(var)3-9 of Drosophila melanogaster encodes a zinc finger protein. Weiler KS. Genetics, 2007 Sep. PMID 17660546, Free PMC Article
    4. Functional characterization and gene expression profiling of Drosophila melanogaster short dADA2b isoform-containing dSAGA complexes. Pankotai T, et al. BMC Genomics, 2013 Jan 22. PMID 23336284, Free PMC Article
    5. A pupal transcriptomic screen identifies Ral as a target of store-operated calcium entry in Drosophila neurons. Richhariya S, et al. Sci Rep, 2017 Feb 14. PMID 28195208, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfotransferase 2
    Names
    CG16733-PA
    CG16733-PB
    St2-PA
    St2-PB
    NP_001287244.1
    NP_649870.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9251843..9253514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300315.1 → NP_001287244.1  sulfotransferase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287244.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R912, Q9VHH0
      Conserved Domains (1) summary
      pfam00685
      Location:55 → 310
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_141613.2 → NP_649870.1  sulfotransferase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649870.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R912, Q9VHH0
      Related
      FBpp0081454
      Conserved Domains (1) summary
      pfam00685
      Location:55 → 310
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHH0 Q9VHH0

    Gene LinkOut

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