U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tpc1 Thiamine pyrophosphate carrier protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41316, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tpc1provided by FlyBase
    Official Full Name
    Thiamine pyrophosphate carrier protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037852
    Locus tag
    Dmel_CG6608
    See related
    AllianceGenome:FB:FBgn0037852
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6608; Dmel\CG6608; DmTpc1; tpc1
    Summary
    Enables antiporter activity and thiamine transmembrane transporter activity. Involved in mitochondrial thiamine pyrophosphate transmembrane transport. Predicted to be active in mitochondrial inner membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic epipharynx; and gut section. Human ortholog(s) of this gene implicated in inherited metabolic disorder and microcephaly. Orthologous to human SLC25A19 (solute carrier family 25 member 19). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tpc1 in Genome Data Viewer
    Location:
    86C7-86C7; 3-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10879572..10882188, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6705294..6707910, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45195 Neighboring gene Sorbitol dehydrogenase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene leash Neighboring gene Adenylate kinase 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transport of platinum bonded nucleotides into proteoliposomes, mediated by Drosophila melanogaster thiamine pyrophosphate carrier protein (DmTpc1). Carrisi C, et al. J Inorg Biochem, 2014 Jan. PMID 24148759
    2. The biochemical properties of the mitochondrial thiamine pyrophosphate carrier from Drosophila melanogaster. Iacopetta D, et al. FEBS J, 2010 Mar. PMID 20121944
    3. The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains. Santana JF, et al. Cell Rep, 2020 Mar 10. PMID 32160531, Free PMC Article
    4. Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster. Iyer J, et al. G3 (Bethesda), 2016 May 3. PMID 26994292, Free PMC Article
    5. Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits. Kanellopoulos AK, et al. Cell, 2020 Mar 19. PMID 32200800

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial thiamine pyrophosphate transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in thiamine pyrophosphate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine pyrophosphate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    thiamine pyrophosphate carrier protein 1
    Names
    CG6608-PA
    CG6608-PB
    Tpc1-PA
    Tpc1-PB
    thiamine pyrophosphate carrier protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10879572..10882188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141777.4 → NP_650034.1  thiamine pyrophosphate carrier protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0L7
      Related
      FBpp0081810
      Conserved Domains (2) summary
      PTZ00169
      Location:33 → 329
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:233 → 328
      Mito_carr; Mitochondrial carrier protein

    2. NM_169372.3 → NP_731527.1  thiamine pyrophosphate carrier protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731527.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0L7
      Related
      FBpp0081809
      Conserved Domains (2) summary
      PTZ00169
      Location:33 → 329
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:233 → 328
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0L7 Q7K0L7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous