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    GstD4 Glutathione S transferase D4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48337, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GstD4provided by FlyBase
    Official Full Name
    Glutathione S transferase D4provided by FlyBase
    Primary source
    FLYBASE:FBgn0010040
    Locus tag
    Dmel_CG11512
    See related
    AllianceGenome:FB:FBgn0010040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11512; Dmel\CG11512; DmGST23; DmGstd4; DmGSTD4; gst; Gst; GST; gstD23; GstD23; gstd4; gstD4; GSTD4
    Summary
    Enables glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstD4 in Genome Data Viewer
    Location:
    87B8-87B8; 3-52 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12374100..12374824)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8199822..8200546)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase D2 Neighboring gene Glutathione S transferase D3 Neighboring gene Glutathione S transferase D5 Neighboring gene Glutathione S transferase D6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary compromises to metabolic toxins: Ammonia and urea tolerance in Drosophila suzukii and Drosophila melanogaster. Belloni V, et al. Physiol Behav, 2018 Jul 1. PMID 29679661
    2. Early-life exposure to tobacco smoke alters airway signaling pathways and later mortality in D. melanogaster. Sirocko KT, et al. Environ Pollut, 2022 Sep 15. PMID 35780997
    3. The glutathione S-transferase D genes. A divergently organized, intronless gene family in Drosophila melanogaster. Toung YP, et al. J Biol Chem, 1993 May 5. PMID 7683659
    4. Increasing autophagy and blocking Nrf2 suppress laminopathy-induced age-dependent cardiac dysfunction and shortened lifespan. Bhide S, et al. Aging Cell, 2018 Jun. PMID 29575479, Free PMC Article
    5. Mitogen-activated protein kinase p38b interaction with delta class glutathione transferases from the fruit fly, Drosophila melanogaster. Wongtrakul J, et al. J Insect Sci, 2012. PMID 23438069, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase D4
    Names
    CG11512-PA
    Glutathione-S-transferase
    GstD4-PA
    glutathione S transferase D23
    NP_524913.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12374100..12374824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080174.4 → NP_524913.1  glutathione S transferase D4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524913.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q541F8, Q9TX90, Q9VG96
      Related
      FBpp0082043
      Conserved Domains (3) summary
      PRK10542
      Location:1 → 184
      PRK10542; glutathionine S-transferase; Provisional
      cd03177
      Location:88 → 204
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      cd03045
      Location:1 → 74
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG96.1 Q9VG96

    Gene LinkOut

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