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    Scgbeta Sarcoglycan beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scgbetaprovided by FlyBase
    Official Full Name
    Sarcoglycan betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038042
    Locus tag
    Dmel_CG5657
    See related
    AllianceGenome:FB:FBgn0038042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5657; Dmel\CG5657; DmSCG-beta; dscgbeta; scg-beta
    Summary
    Predicted to be a structural constituent of muscle. Predicted to be involved in muscle organ development. Predicted to be located in membrane. Predicted to be part of sarcoglycan complex. Predicted to be active in sarcolemma. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; labral sensory complex primordium; and larval central nervous system. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2E and muscular dystrophy. Orthologous to human SGCB (sarcoglycan beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Scgbeta in Genome Data Viewer
    Location:
    87B9-87B9; 3-52 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12421236..12422429, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8246958..8248151, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dipeptidase C Neighboring gene small non-coding RNA 649 Neighboring gene protein partner of snf Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase 1 at 87B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic changes in the subcellular localization of Drosophila beta-sarcoglycan during the cell cycle. Hashimoto R, et al. Cell Struct Funct, 2006. PMID 17159290
    2. Conservation of components of the dystrophin complex in Drosophila. Greener MJ, et al. FEBS Lett, 2000 Sep 29. PMID 11018515
    3. Embryonic expression patterns of the Drosophila dystrophin-associated glycoprotein complex orthologs. Dekkers LC, et al. Gene Expr Patterns, 2004 Mar. PMID 15161095
    4. The roles of the dystrophin-associated glycoprotein complex at the synapse. Pilgram GS, et al. Mol Neurobiol, 2010 Feb. PMID 19899002, Free PMC Article
    5. Genetic link between beta-sarcoglycan and the Egfr signaling pathway. Hashimoto R, et al. Biochem Biophys Res Commun, 2006 Sep 15. PMID 16875661

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sarcoglycan complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sarcoglycan complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sarcoglycan complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sarcoglycan beta
    Names
    CG5657-PA
    Scgbeta-PA
    beta-sarcoglycan
    beta-sarcolgycan

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12421236..12422429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079603.3 → NP_524327.1  sarcoglycan beta [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524327.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GT65, Q9VG77
      Related
      FBpp0082068
      Conserved Domains (1) summary
      pfam04790
      Location:73 → 330
      Sarcoglycan_1; Sarcoglycan complex subunit protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GT65 Q9GT65
    Q9VG77 Q9VG77

    Gene LinkOut

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