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    Desat2 Desaturase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Desat2provided by FlyBase
    Official Full Name
    Desaturase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0043043
    Locus tag
    Dmel_CG5925
    See related
    AllianceGenome:FB:FBgn0043043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    7-11HD; CG5925; desat; desat 2; desat-2; desat2; desat2/Fad; Dmel NPTQ; Dmel NPTQ Z9; Dmel\CG5925; ds2; Fad
    Summary
    Predicted to enable iron ion binding activity and stearoyl-CoA 9-desaturase activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to several human genes including SCD5 (stearoyl-CoA desaturase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Desat2 in Genome Data Viewer
    Location:
    87B10-87B10; 3-52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12436248..12437857)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8261970..8263579)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Proteasome alpha2 subunit Neighboring gene Activator of SUMO 1 Neighboring gene Spliceosome-ribosome linker protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Desaturase 1 Neighboring gene versager

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutation in the promoter of desaturase 2 is correlated with sexual isolation between Drosophila behavioral races. Fang S, et al. Genetics, 2002 Oct. PMID 12399388, Free PMC Article
    2. Ecological adaptation during incipient speciation revealed by precise gene replacement. Greenberg AJ, et al. Science, 2003 Dec 5. PMID 14657496
    3. Does the desaturase-2 locus in Drosophila melanogaster cause adaptation and sexual isolation? Coyne JA, et al. Evolution, 2006 Feb. PMID 16610320
    4. African morphology, behavior and phermones underlie incipient sexual isolation between us and Caribbean Drosophila melanogaster. Yukilevich R, et al. Evolution, 2008 Nov. PMID 18752599
    5. Deletions in the desaturase2 gene in Israeli populations of Drosophila melanogaster: possible role in mate recognition. Zamorzaeva I, et al. Insect Mol Biol, 2009 Feb. PMID 19054159

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The allele with an additional deletion in exon 1 seems to play some role in mating success, which is associated with shorter courtship latency and courtship duration
      Title: Deletions in the desaturase2 gene in Israeli populations of Drosophila melanogaster: possible role in mate recognition.
    2. Geographical variation at the pheromone locus desaturase-2, and morphology and courtship behavior across the US-Caribbean region.
      Title: African morphology, behavior and phermones underlie incipient sexual isolation between us and Caribbean Drosophila melanogaster.
    3. an allele of ds2 from the Zimbabwe population was introduced into Cosmopolitan flies; results show the Cosmopolitan allele confers resistance to cold as well as susceptibility to starvation when the entire genetic background is otherwise identical
      Title: Ecological adaptation during incipient speciation revealed by precise gene replacement.
    4. This study failed replicate earlier results showing that carriers of M alleles are uniformly more cold resistant and less starvation resistant than carriers of Z alleles; it did demonstrate some evidence for sexual isolation due to desat2.
      Title: Does the desaturase-2 locus in Drosophila melanogaster cause adaptation and sexual isolation?
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables stearoyl-CoA 9-desaturase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables stearoyl-CoA 9-desaturase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    desaturase 2
    Names
    7,11-heptacosadiene modifier
    CG5925-PA
    Desat2-PA
    Desaturase2
    desat2
    desaturase
    desaturase-2
    fatty acid desaturase
    NP_650201.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12436248..12437857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141944.3 → NP_650201.1  desaturase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BH57, Q9BLE1, Q9N9Z8, Q9VG68
      Related
      FBpp0082064
      Conserved Domains (2) summary
      cd03505
      Location:76 → 317
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
      pfam00487
      Location:81 → 284
      FA_desaturase; Fatty acid desaturase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BLE1 Q9BLE1
    Q9N9Z8 Q9N9Z8
    Q9VG68 Q9VG68

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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