U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG42788 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41817, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG42788provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261859
    Locus tag
    Dmel_CG42788
    See related
    AllianceGenome:FB:FBgn0261859
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.79; CG18442; CG31304; CG6934; CG6960; Dmel\CG42788
    Old locus tag
    Dmel_CG31304; Dmel_CG6934
    Summary
    Predicted to be involved in signal transduction. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in adult head; gonad; larval muscle system; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 104. Orthologous to several human genes including FRMPD4 (FERM and PDZ domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG42788 in Genome Data Viewer
    Location:
    88E1-88E2; 3-56 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15095957..15131926, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10921679..10957648, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-2493 stem loop Neighboring gene antisense RNA:CR45600 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks. Cannavò E, et al. Curr Biol, 2016 Jan 11. PMID 26687625, Free PMC Article
    2. Regulatory regions in natural transposable element insertions drive interindividual differences in response to immune challenges in Drosophila. Ullastres A, et al. Genome Biol, 2021 Sep 14. PMID 34521452, Free PMC Article
    3. Enhancer redundancy in development and disease. Kvon EZ, et al. Nat Rev Genet, 2021 May. PMID 33442000, Free PMC Article
    4. Parallel and population-specific gene regulatory evolution in cold-adapted fly populations. Huang Y, et al. Genetics, 2021 Jul 14. PMID 33989401, Free PMC Article
    5. Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development. Ou Q, et al. PLoS Biol, 2011 Sep. PMID 21980261, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: c15109750-15102553 mobile_element_type = transposon:412{}1365

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG42788-PB
    CG42788-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15095957..15131926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202293.3 → NP_001189222.1  uncharacterized protein Dmel_CG42788, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189222.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JDC8
      Conserved Domains (7) summary
      smart00295
      Location:396 → 617
      B41; Band 4.1 homologues
      cd00201
      Location:218 → 246
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:257 → 333
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00373
      Location:495 → 617
      FERM_M; FERM central domain
      pfam00397
      Location:177 → 203
      WW; WW domain
      cl00155
      Location:396 → 477
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:613 → 714
      PH-like; Pleckstrin homology-like domain

    2. NM_169609.4 → NP_731964.2  uncharacterized protein Dmel_CG42788, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731964.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFD3
      Conserved Domains (7) summary
      smart00295
      Location:396 → 617
      B41; Band 4.1 homologues
      cd00201
      Location:218 → 246
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:257 → 333
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00373
      Location:495 → 617
      FERM_M; FERM central domain
      pfam00397
      Location:177 → 203
      WW; WW domain
      cl00155
      Location:396 → 477
      UBQ; Ubiquitin-like proteins
      cl17171
      Location:613 → 715
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JDC8 A0A0B4JDC8
    Q9VFD3 Q9VFD3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools