U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tmtc4 Transmembrane O-mannosyltransferase targeting cadherins 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41867, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tmtc4provided by FlyBase
    Official Full Name
    Transmembrane O-mannosyltransferase targeting cadherins 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0038324
    Locus tag
    Dmel_CG5038
    See related
    AllianceGenome:FB:FBgn0038324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5038; Dmel\CG5038; TMTC4
    Summary
    Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and protein O-linked mannosylation. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human TMTC4 (transmembrane O-mannosyltransferase targeting cadherins 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tmtc4 in Genome Data Viewer
    Location:
    88F1-88F1; 3-57 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15351225..15353926)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11176947..11179648)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TRAPP subunit 33 Neighboring gene Autophagy-related 4b Neighboring gene 3-hydroxyisobutyryl-CoA hydrolase Neighboring gene Component of oligomeric golgi complex 2 Neighboring gene Translin associated factor X Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites. Eisenhaber B, et al. Biol Direct, 2021 Jan 12. PMID 33436046, Free PMC Article
    2. Protein O-mannosylation: one sugar, several pathways, many functions. Koff M, et al. Glycobiology, 2023 Dec 25. PMID 37565810, Free PMC Article
    3. An endogenous small interfering RNA pathway in Drosophila. Czech B, et al. Nature, 2008 Jun 5. PMID 18463631, Free PMC Article
    4. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article
    5. GlycoFly: a database of Drosophila N-linked glycoproteins identified using SPEG--MS techniques. Baycin-Hizal D, et al. J Proteome Res, 2011 Jun 3. PMID 21480662

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked mannosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transmembrane O-mannosyltransferase targeting cadherins 4
    Names
    CG5038-PA
    Tmtc4-PA
    NP_650451.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15351225..15353926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142194.3 → NP_650451.1  transmembrane O-mannosyltransferase targeting cadherins 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650451.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VF81
      Related
      FBpp0082545
      Conserved Domains (5) summary
      COG0457
      Location:442 → 701
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:480 → 506
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:546 → 577
      TPR_1; Tetratricopeptide repeat
      pfam08409
      Location:258 → 331
      DUF1736; Domain of unknown function (DUF1736)
      pfam13431
      Location:466 → 499
      TPR_17; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VF81.1 Q9VF81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools