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    CG43102 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG43102provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262562
    Locus tag
    Dmel_CG43102
    See related
    AllianceGenome:FB:FBgn0262562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ARHGEF17; CG14318; CG7397; Dmel\CG43102
    Old locus tag
    Dmel_CG14318; Dmel_CG7397
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization and positive regulation of Rho protein signal transduction. Predicted to be active in cytoplasm. Is expressed in leg joint; primary tracheal branch; and spermatozoon. Orthologous to human ARHGEF17 (Rho guanine nucleotide exchange factor 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG43102 in Genome Data Viewer
    Location:
    90C3-90C5; 3-61 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17768272..17794490, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13593994..13620212, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tyramine receptor II Neighboring gene Tyramine receptor Neighboring gene pasiflora 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genetic basis of variation in Drosophila melanogaster mating behavior. Yamamoto A, et al. iScience, 2024 May 17. PMID 38766354, Free PMC Article
    2. Change in RhoGAP and RhoGEF availability drives transitions in cortical patterning and excitability in Drosophila. Jackson JA, et al. Curr Biol, 2024 May 20. PMID 38688282,
    3. Adult Drosophila sensory neurons specify dendritic territories independently of dendritic contacts through the Wnt5-Drl signaling pathway. Yasunaga K, et al. Genes Dev, 2015 Aug 15. PMID 26302791, Free PMC Article
    4. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article
    5. Cadmium-induced genome-wide DNA methylation changes in growth and oxidative metabolism in Drosophila melanogaster. Guan DL, et al. BMC Genomics, 2019 May 9. PMID 31072326, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG43102-PA
    CG43102-PB
    CG43102-PC
    CG43102-PD
    CG43102-PE
    CG43102-PF
    CG43102-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17768272..17794490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260226.2 → NP_001247155.1  uncharacterized protein Dmel_CG43102, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247155.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEF7
      Conserved Domains (2) summary
      pfam00621
      Location:1505 → 1687
      RhoGEF; RhoGEF domain
      cl17171
      Location:1679 → 1818
      PH-like; Pleckstrin homology-like domain

    2. NM_001275755.2 → NP_001262684.1  uncharacterized protein Dmel_CG43102, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262684.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHP1
      Conserved Domains (2) summary
      pfam00621
      Location:1505 → 1687
      RhoGEF; RhoGEF domain
      cl17171
      Location:1679 → 1818
      PH-like; Pleckstrin homology-like domain

    3. NM_142397.3 → NP_650654.2  uncharacterized protein Dmel_CG43102, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650654.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEF7
      Conserved Domains (2) summary
      pfam00621
      Location:1505 → 1687
      RhoGEF; RhoGEF domain
      cl17171
      Location:1679 → 1818
      PH-like; Pleckstrin homology-like domain

    4. NM_001260227.2 → NP_001247156.1  uncharacterized protein Dmel_CG43102, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247156.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6L3
      Conserved Domains (2) summary
      pfam00621
      Location:1576 → 1758
      RhoGEF; RhoGEF domain
      cl17171
      Location:1750 → 1889
      PH-like; Pleckstrin homology-like domain

    5. NM_001300454.1 → NP_001287383.1  uncharacterized protein Dmel_CG43102, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287383.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LIC0
      Conserved Domains (3) summary
      pfam00621
      Location:932 → 1114
      RhoGEF; RhoGEF domain
      sd00039
      Location:1592 → 1643
      7WD40; WD40 repeat [structural motif]
      cl17171
      Location:1106 → 1245
      PH-like; Pleckstrin homology-like domain

    6. NM_001260228.2 → NP_001247157.1  uncharacterized protein Dmel_CG43102, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247157.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K728
      Conserved Domains (3) summary
      pfam00621
      Location:599 → 781
      RhoGEF; RhoGEF domain
      sd00039
      Location:1259 → 1310
      7WD40; WD40 repeat [structural motif]
      cl17171
      Location:773 → 912
      PH-like; Pleckstrin homology-like domain

    7. NM_142396.3 → NP_650653.1  uncharacterized protein Dmel_CG43102, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEF9
      Related
      FBpp0293550
      Conserved Domains (1) summary
      pfam00621
      Location:158 → 340
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6L3 A0A0B4K6L3
    A0A0B4K728 A0A0B4K728
    A0A0B4KHP1 A0A0B4KHP1
    A0A0B4LIC0 A0A0B4LIC0
    Q9VEF7 Q9VEF7
    Q9VEF9 Q9VEF9

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