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    Root Rootletin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42860, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rootprovided by FlyBase
    Official Full Name
    Rootletinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039152
    Locus tag
    Dmel_CG6129
    See related
    AllianceGenome:FB:FBgn0039152
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6129; Dmel\CG6129; Q8IMX3_DROME
    Summary
    Involved in auditory behavior; ciliary basal body organization; and sensory perception of mechanical stimulus. Colocalizes with ciliary rootlet. Is expressed in antenna; chordotonal organ precursor cell; sense organ; sensory neurons; and spermatozoon. Orthologous to several human genes including CROCC (ciliary rootlet coiled-coil, rootletin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Root in Genome Data Viewer
    Location:
    95E1-95E1; 3-83 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24113286..24128193)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19939008..19953915)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Leucine-TAA 2-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutamyl-tRNA amidotransferase, subunit B Neighboring gene Tsc1 Neighboring gene Secretory 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila homologue of Rootletin is required for mechanosensory function and ciliary rootlet formation in chordotonal sensory neurons. Styczynska-Soczka K, et al. Cilia, 2015. PMID 26140210, Free PMC Article
    2. Sas-4 Colocalizes with the Ciliary Rootlets of the Drosophila Sensory Organs. Persico V, et al. J Dev Biol, 2021 Jan 5. PMID 33466292, Free PMC Article
    3. Tissue specific requirement of Drosophila Rcd4 for centriole duplication and ciliogenesis. Panda P, et al. J Cell Biol, 2020 Sep 7. PMID 32543652, Free PMC Article
    4. Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila. Chen JV, et al. J Cell Biol, 2015 Oct 26. PMID 26483560, Free PMC Article
    5. Gene regulation by the lysine demethylase KDM4A in Drosophila. Crona F, et al. Dev Biol, 2013 Jan 15. PMID 23195220

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in auditory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ciliary basal body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of touch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rootletin
    Names
    CG6129-PD
    CG6129-PE
    CG6129-PF
    Root-PD
    Root-PE
    Root-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24113286..24128193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300568.1 → NP_001287497.1  rootletin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287497.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCD1
      Conserved Domains (3) summary
      COG1196
      Location:555 → 1384
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:991 → 1779
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:110 → 332
      Rootletin; Ciliary rootlet component, centrosome cohesion

    2. NM_142959.4 → NP_651216.2  rootletin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651216.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCD1
      Related
      FBpp0293091
      Conserved Domains (3) summary
      COG1196
      Location:555 → 1384
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:991 → 1779
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:110 → 332
      Rootletin; Ciliary rootlet component, centrosome cohesion

    3. NM_176553.2 → NP_788730.2  rootletin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788730.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCD1
      Conserved Domains (3) summary
      COG1196
      Location:555 → 1384
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:991 → 1779
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:110 → 332
      Rootletin; Ciliary rootlet component, centrosome cohesion
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSN3 Q8MSN3
    Q9VCD1 Q9VCD1

    Gene LinkOut

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