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    Myo95E Myosin 95E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768680, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myo95Eprovided by FlyBase
    Official Full Name
    Myosin 95Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039157
    Locus tag
    Dmel_CG5501
    See related
    AllianceGenome:FB:FBgn0039157
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    95E; CG31134; CG31135; CG5501; Dm95E; DmAE003746; Dmel\CG5501; myo 95E; Myo5
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization; actin filament-based movement; and endocytosis. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human MYO1A (myosin IA) and MYO1B (myosin IB). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Myo95E in Genome Data Viewer
    Location:
    95E6-95E6; 3-83 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24154826..24161498, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19980548..19987220, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene p38c MAP kinase Neighboring gene p38a MAP kinase Neighboring gene uncharacterized protein Neighboring gene TBC1 domain family member 7 Neighboring gene mitochondrial ribosomal protein S24 Neighboring gene Adenomatous polyposis coli 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Class I myosins have overlapping and specialized functions in left-right asymmetric development in Drosophila. Okumura T, et al. Genetics, 2015 Apr. PMID 25659376, Free PMC Article
    2. Cell Chirality Drives Left-Right Asymmetric Morphogenesis. Inaki M, et al. Front Cell Dev Biol, 2018. PMID 29666795, Free PMC Article
    3. Molecular to organismal chirality is induced by the conserved myosin 1D. Lebreton G, et al. Science, 2018 Nov 23. PMID 30467170, Free PMC Article
    4. A millennial myosin census. Berg JS, et al. Mol Biol Cell, 2001 Apr. PMID 11294886, Free PMC Article
    5. Identification and phylogenetic analysis of Drosophila melanogaster myosins. Tzolovsky G, et al. Mol Biol Evol, 2002 Jul. PMID 12082124

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin 95E
    Names
    CG5501-PB
    CG5501-PD
    CG5501-PE
    CG5501-PF
    CG5501-PG
    CG5501-PJ
    Myo95E-PB
    Myo95E-PD
    Myo95E-PE
    Myo95E-PF
    Myo95E-PG
    Myo95E-PJ
    Myosin95E
    NP_001027204.2
    NP_001027206.1
    NP_001027207.1
    NP_001027208.1
    NP_996278.1
    NP_996279.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24154826..24161498 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206556.2 → NP_996279.1  myosin 95E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996279.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4AB26, Q8T6L6
      Conserved Domains (2) summary
      cl22853
      Location:403 → 914
      Motor_domain; Myosin and Kinesin motor domain
      pfam06017
      Location:1062 → 1237
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    2. NM_206555.2 → NP_996278.1  myosin 95E, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996278.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T6L7
      Conserved Domains (2) summary
      cl22853
      Location:403 → 914
      Motor_domain; Myosin and Kinesin motor domain
      pfam06017
      Location:1082 → 1257
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    3. NM_001032035.2 → NP_001027206.1  myosin 95E, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027206.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4AB24
      Conserved Domains (2) summary
      cl22853
      Location:19 → 118
      Motor_domain; Myosin and Kinesin motor domain
      pfam15814
      Location:106 → 207
      FAM199X; Protein family FAM199X

    4. NM_001032037.2 → NP_001027208.1  myosin 95E, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4AB27
      Conserved Domains (2) summary
      cl22853
      Location:403 → 924
      Motor_domain; Myosin and Kinesin motor domain
      pfam06017
      Location:1092 → 1267
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    5. NM_001032033.2 → NP_001027204.2  myosin 95E, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027204.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4AB26, Q8T6L6
      Conserved Domains (2) summary
      cl22853
      Location:403 → 914
      Motor_domain; Myosin and Kinesin motor domain
      pfam06017
      Location:1062 → 1237
      Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

    6. NM_001032036.2 → NP_001027207.1  myosin 95E, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4AB24
      Conserved Domains (2) summary
      cl22853
      Location:19 → 118
      Motor_domain; Myosin and Kinesin motor domain
      pfam15814
      Location:106 → 207
      FAM199X; Protein family FAM199X
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4AB24 Q4AB24
    Q4AB27 Q4AB27
    Q8T6L6 Q8T6L6
    Q8T6L7 Q8T6L7
    Q961G2 Q961G2

    Gene LinkOut

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