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    niki nimA-like kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42959, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nikiprovided by FlyBase
    Official Full Name
    nimA-like kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0045980
    Locus tag
    Dmel_CG10951
    See related
    AllianceGenome:FB:FBgn0045980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10951; Dmel\CG10951; NEK1; Niki
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be located in cilium. Predicted to be active in nucleus. Used to study amyotrophic lateral sclerosis type 24. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome; nephronophthisis 9; and renal-hepatic-pancreatic dysplasia. Orthologous to several human genes including NEK9 (NIMA related kinase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See niki in Genome Data Viewer
    Location:
    96A23-96A24; 3-85 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24822401..24825648, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20648123..20651370, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46096 Neighboring gene uncharacterized protein Neighboring gene Scaffold attachment factor B Neighboring gene long non-coding RNA:CR43166 Neighboring gene RabX4 Neighboring gene Katazuke

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import. Mann JR, et al. Sci Adv, 2023 Aug 18. PMID 37585529, Free PMC Article
    2. High-resolution SNP mapping by denaturing HPLC. Nairz K, et al. Proc Natl Acad Sci U S A, 2002 Aug 6. PMID 12149455, Free PMC Article
    3. Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure. Prigent C, et al. Exp Cell Res, 2005 Feb 1. PMID 15572022
    4. A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatids. Basiri ML, et al. Curr Biol, 2014 Nov 17. PMID 25447994, Free PMC Article
    5. Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye. Zhang T, et al. Dev Dyn, 2005 Nov. PMID 16145661

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nimA-like kinase
    Names
    CG10951-PA
    niki-PA
    NP_651293.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24822401..24825648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143036.2 → NP_651293.1  nimA-like kinase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651293.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VC32
      Related
      FBpp0084112
      Conserved Domains (3) summary
      smart00220
      Location:105 → 354
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG5184
      Location:445 → 747
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd08215
      Location:104 → 359
      STKc_Nek; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VC32 Q9VC32

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