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    superdeath Suppressor of ER stress-induced death [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    superdeathprovided by FlyBase
    Official Full Name
    Suppressor of ER stress-induced deathprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039640
    Locus tag
    Dmel_CG14516
    See related
    AllianceGenome:FB:FBgn0039640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14516; Dmel\CG14516
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; embryonic anal pad; germline cell; gonad; and indirect flight muscle cell. Orthologous to human ANPEP (alanyl aminopeptidase, membrane). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See superdeath in Genome Data Viewer
    Location:
    98F12-98F12; 3-97 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29138662..29145787)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24964384..24971509)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene dim gamma-tubulin 6 Neighboring gene Vacuolar H[+] ATPase 100kD subunit 1 Neighboring gene Alg13 UDP-N-acetylglucosaminyltransferase subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphoglyceromutase 78 Neighboring gene eukaryotic translation initiation factor 2D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Decoupling of Apoptosis from Activation of the ER Stress Response by the Drosophila Metallopeptidase superdeath. Palu RAS, et al. Genetics, 2020 Apr. PMID 32047096, Free PMC Article
    2. julius seizure, a Drosophila Mutant, Defines a Neuronal Population Underlying Epileptogenesis. Horne M, et al. Genetics, 2017 Mar. PMID 28082408, Free PMC Article
    3. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115
    4. Overexpression of miRNA-9 Generates Muscle Hypercontraction Through Translational Repression of Troponin-T in Drosophila melanogaster Indirect Flight Muscles. Katti P, et al. G3 (Bethesda), 2017 Oct 5. PMID 28866639, Free PMC Article
    5. Altered levels of hsromega lncRNAs further enhance Ras signaling during ectopically activated Ras induced R7 differentiation in Drosophila. Ray M, et al. Gene Expr Patterns, 2019 Sep. PMID 31096022

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decoupling of Apoptosis from Activation of the ER Stress Response by the Drosophila Metallopeptidase superdeath.
      Title: Decoupling of Apoptosis from Activation of the ER Stress Response by the Drosophila Metallopeptidase superdeath.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of ER stress-induced death
    Names
    CG14516-PA
    CG14516-PB
    CG14516-PC
    SUPpressor of ER stress-induced DEATH
    superdeath-PA
    superdeath-PB
    superdeath-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29138662..29145787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143417.3 → NP_651674.3  suppressor of ER stress-induced death, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651674.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KRW4
      Related
      FBpp0084751
      Conserved Domains (3) summary
      cd09601
      Location:121 → 576
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:113 → 505
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:652 → 974
      ERAP1_C; ERAP1-like C-terminal domain

    2. NM_170398.2 → NP_733277.1  suppressor of ER stress-induced death, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733277.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAP0
      Related
      FBpp0084752
      Conserved Domains (3) summary
      cd09601
      Location:112 → 567
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:104 → 496
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:643 → 965
      ERAP1_C; ERAP1-like C-terminal domain

    3. NM_001276126.1 → NP_001263055.1  suppressor of ER stress-induced death, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAP0
      Conserved Domains (3) summary
      cd09601
      Location:112 → 567
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:104 → 496
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:643 → 965
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KRW4 Q7KRW4
    Q8SYT3 Q8SYT3
    Q9VAP0 Q9VAP0

    Gene LinkOut

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