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    Asator asator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43794, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asatorprovided by FlyBase
    Official Full Name
    asatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039908
    Locus tag
    Dmel_CG11533
    See related
    AllianceGenome:FB:FBgn0039908
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11533; CK I; CKI-like; Dmel\CG11533
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in signal transduction. Located in cytoplasm and spindle. Is expressed in adult head. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK1 (tau tubulin kinase 1) and TTBK2 (tau tubulin kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Asator in Genome Data Viewer
    Location:
    102C1-102C1; 4-0 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (469409..488994, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (490035..509620, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene Calcium/calmodulin-dependent protein kinase I Neighboring gene antisense RNA:CR45126 Neighboring gene TBP-associated factor 3 Neighboring gene uncharacterized protein Neighboring gene Zn finger homeodomain 2 Neighboring gene long non-coding RNA:CR43958 Neighboring gene Thymine DNA glycosylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Asator, a tau-tubulin kinase homolog in Drosophila localizes to the mitotic spindle. Qi H, et al. Dev Dyn, 2009 Dec. PMID 19890914
    2. Discovery of supernumerary B chromosomes in Drosophila melanogaster. Bauerly E, et al. Genetics, 2014 Apr. PMID 24478336, Free PMC Article
    3. Molecular mapping of deletion breakpoints on chromosome 4 of Drosophila melanogaster. Podemski L, et al. Chromosoma, 2004 Jun. PMID 15185094
    4. Anterior repression of a Drosophila stripe enhancer requires three position-specific mechanisms. Andrioli LP, et al. Development, 2002 Nov. PMID 12397102
    5. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Kramps T, et al. Cell, 2002 Apr 5. PMID 11955446

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c476399-476344 mobile_element_type = transposon:INE-1{}5932
    • Loc: c476483-476402 mobile_element_type = transposon:INE-1{}5934

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    asator
    Names
    Asator-PD
    Asator-PE
    Asator-PF
    Asator-PG
    Asator-PH
    Asator-PI
    Asator-PJ
    Asator-PK
    Asator-PL
    CG11533-PD
    CG11533-PE
    CG11533-PF
    CG11533-PG
    CG11533-PH
    CG11533-PI
    CG11533-PJ
    CG11533-PK
    CG11533-PL
    NP_001259054.1
    NP_001259055.1
    NP_001259056.1
    NP_001259057.1
    NP_001259058.1
    NP_001284714.1
    NP_651924.2
    NP_726576.2
    NP_726577.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      469409..488994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272127.1 → NP_001259056.1  asator, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E766, L0MPX5
      Conserved Domains (2) summary
      smart00220
      Location:172 → 413
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14017
      Location:171 → 432
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

    2. NM_166766.3 → NP_726577.2  asator, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726577.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IMC6
      Conserved Domains (2) summary
      smart00220
      Location:17 → 258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14017
      Location:16 → 277
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

    3. NM_001272126.2 → NP_001259055.1  asator, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259055.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E766, L0MPN7
      Conserved Domains (2) summary
      smart00220
      Location:17 → 258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14017
      Location:16 → 277
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

    4. NM_143667.3 → NP_651924.2  asator, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651924.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E766, Q9V4D6
      Conserved Domains (2) summary
      smart00220
      Location:173 → 414
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14017
      Location:172 → 433
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

    5. NM_001297785.1 → NP_001284714.1  asator, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284714.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E766, L0MLN1
      Conserved Domains (2) summary
      smart00220
      Location:17 → 258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14017
      Location:16 → 277
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

    6. NM_001272128.1 → NP_001259057.1  asator, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259057.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E766, L0MN72
      Conserved Domains (2) summary
      smart00220
      Location:172 → 413
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14017
      Location:171 → 432
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

    7. NM_001272129.1 → NP_001259058.1  asator, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259058.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E766, L0MLN1
      Conserved Domains (2) summary
      smart00220
      Location:17 → 258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14017
      Location:16 → 277
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

    8. NM_001272125.1 → NP_001259054.1  asator, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E766, L0MLK2
      Conserved Domains (2) summary
      smart00220
      Location:173 → 414
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14017
      Location:172 → 433
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

    9. NM_166765.3 → NP_726576.2  asator, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726576.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IMC5, Q8IMC6
      UniProtKB/TrEMBL
      A8E766
      Conserved Domains (1) summary
      cd14017
      Location:172 → 433
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    L0MLK2 L0MLK2
    L0MLN1 L0MLN1
    L0MN72 L0MN72
    L0MPN7 L0MPN7
    L0MPX5 L0MPX5
    Q8IMC6.2 Q8IMC6
    Q9V4D6 Q9V4D6

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