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    LPCAT Lysophosphatidylcholine acyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LPCATprovided by FlyBase
    Official Full Name
    Lysophosphatidylcholine acyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052699
    Locus tag
    Dmel_CG32699
    See related
    AllianceGenome:FB:FBgn0052699
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15318; CG18535; CG2996; CG32699; CT7882; Dmel\CG32699; LPCAT1/2; tok-like
    Summary
    Enables lysophospholipid acyltransferase activity. Involved in lipid modification. Located in lipid droplet. Is expressed in adult head. Orthologous to several human genes including LPCAT1 (lysophosphatidylcholine acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LPCAT in Genome Data Viewer
    Location:
    8E10-8E10; 1-28 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9571537..9579987, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9465570..9474020, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42767 Neighboring gene Cubilin Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45540 Neighboring gene long non-coding RNA:CR45541

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two different pathways of phosphatidylcholine synthesis, the Kennedy Pathway and the Lands Cycle, differentially regulate cellular triacylglycerol storage. Moessinger C, et al. BMC Cell Biol, 2014 Dec 10. PMID 25491198, Free PMC Article
    2. ER responses play a key role in Swiss-Cheese/Neuropathy Target Esterase-associated neurodegeneration. Sunderhaus ER, et al. Neurobiol Dis, 2019 Oct. PMID 31233884, Free PMC Article
    3. Drosophila oocyte proteome composition covaries with female mating status. McDonough-Goldstein CE, et al. Sci Rep, 2021 Feb 4. PMID 33542461, Free PMC Article
    4. Identification of two pathways mediating protein targeting from ER to lipid droplets. Song J, et al. Nat Cell Biol, 2022 Sep. PMID 36050470, Free PMC Article
    5. RNA editing in Drosophila melanogaster: New targets and functional consequences. Stapleton M, et al. RNA, 2006 Nov. PMID 17018572, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-acylglycerophosphocholine O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipid acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysophosphatidylcholine acyltransferase
    Names
    CG32699-PB
    LPCAT-PB
    Lyso-PA acyltransferase
    NP_001036265.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9571537..9579987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042800.3 → NP_001036265.1  lysophosphatidylcholine acyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036265.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHU5, Q86NX4, Q95SE4, Q9W331
      Conserved Domains (3) summary
      cd07991
      Location:126 → 338
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:87 → 265
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      pfam13833
      Location:455 → 507
      EF-hand_8; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KHU5.1 Q0KHU5

    Gene LinkOut

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