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    FoxK Forkhead box K [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FoxKprovided by FlyBase
    Official Full Name
    Forkhead box Kprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036134
    Locus tag
    Dmel_CG11799
    See related
    AllianceGenome:FB:FBgn0036134
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11799; dFoxK; Dmel\CG11799; DmLD16137; DmMNF; fd68A; fork head transcription factor long isoform; fork head transcription factor short isoform; Mnf; MNF
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of gene expression; response to virus; and visceral mesoderm-endoderm interaction involved in midgut development. Is expressed in several structures, including anterior-posterior subdivision of organism; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and ganglia. Orthologous to several human genes including FOXK2 (forkhead box K2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FoxK in Genome Data Viewer
    Location:
    68A7-68A7; 3-34 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11114169..11120783, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11107269..11113883, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene emei Neighboring gene Superoxide dismutase 1 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene Ubiquitin fusion-degradation 1-like Neighboring gene Na[+]-dependent inorganic phosphate cotransporter type III Neighboring gene no optic lobe

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogaster. Ponton F, et al. J Insect Physiol, 2011 Jun. PMID 21435341
    2. FoxK mediates TGF-beta signalling during midgut differentiation in flies. Casas-Tinto S, et al. J Cell Biol, 2008 Dec 15. PMID 19075113, Free PMC Article
    3. The transcription factor FoxK participates with Nup98 to regulate antiviral gene expression. Panda D, et al. mBio, 2015 Apr 7. PMID 25852164, Free PMC Article
    4. Survey of forkhead domain encoding genes in the Drosophila genome: Classification and embryonic expression patterns. Lee HH, et al. Dev Dyn, 2004 Feb. PMID 14745961
    5. Phylogenetic relationships of the Fox (Forkhead) gene family in the Bilateria. Mazet F, et al. Gene, 2003 Oct 16. PMID 14563554

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in midgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visceral mesoderm-endoderm interaction involved in midgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    forkhead box K
    Names
    CG11799-PG
    CG11799-PH
    CG11799-PI
    CG11799-PJ
    CG11799-PK
    CG11799-PN
    CG11799-PO
    CG11799-PP
    FoxK-PG
    FoxK-PH
    FoxK-PI
    FoxK-PJ
    FoxK-PK
    FoxK-PN
    FoxK-PO
    FoxK-PP
    Mnf
    fork head box K
    forkhead domain 68A
    myocyte nuclear factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11114169..11120783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274773.2 → NP_001261702.1  forkhead box K, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261702.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI07
      Conserved Domains (2) summary
      cd00060
      Location:170 → 253
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:452 → 539
      Forkhead; Forkhead domain

    2. NM_001274772.2 → NP_001261701.1  forkhead box K, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261701.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF47
      Conserved Domains (2) summary
      cd00060
      Location:170 → 253
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:453 → 540
      Forkhead; Forkhead domain

    3. NM_168443.3 → NP_729672.1  forkhead box K, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8F8
      Related
      FBpp0291179
      Conserved Domains (2) summary
      cd00060
      Location:170 → 253
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:447 → 534
      Forkhead; Forkhead domain

    4. NM_168446.2 → NP_729675.2  forkhead box K, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729675.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QQA9, Q8IQE9
      Conserved Domains (2) summary
      cd00060
      Location:170 → 253
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:453 → 540
      Forkhead; Forkhead domain

    5. NM_168444.2 → NP_729673.2  forkhead box K, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729673.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QQA9, Q8IQE9
      Conserved Domains (2) summary
      cd00060
      Location:170 → 253
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:453 → 540
      Forkhead; Forkhead domain

    6. NM_001274774.2 → NP_001261703.1  forkhead box K, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261703.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC64
      Conserved Domains (2) summary
      cd00060
      Location:170 → 253
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:453 → 540
      Forkhead; Forkhead domain

    7. NM_140183.3 → NP_648440.2  forkhead box K, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648440.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QQA9, Q8IQE9
      Conserved Domains (2) summary
      cd00060
      Location:170 → 253
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:453 → 540
      Forkhead; Forkhead domain

    8. NM_168445.3 → NP_729674.2  forkhead box K, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729674.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QQA9, Q8IQE9
      Conserved Domains (2) summary
      cd00060
      Location:170 → 253
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00250
      Location:453 → 540
      Forkhead; Forkhead domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JL24 A0JL24
    M9PC64 M9PC64
    M9PF47 M9PF47
    M9PI07 M9PI07
    Q0E8F8 Q0E8F8
    Q8IQE9 Q8IQE9
    Q95RQ3 Q95RQ3
    Q95RS1 Q95RS1

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