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    UQCR-C1 Ubiquinol-cytochrome c reductase core protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41800, updated on 9-Dec-2024

    Summary

    Official Symbol
    UQCR-C1provided by FlyBase
    Official Full Name
    Ubiquinol-cytochrome c reductase core protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038271
    Locus tag
    Dmel_CG3731
    See related
    AllianceGenome:FB:FBgn0038271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 3731; CG3731; Dmel\CG3731; Mpp; MPPB; UCR1; UQCR-cp1; uqcrc1
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and mesoderm. Used to study late onset Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple mitochondrial dysfunctions syndrome 6. Orthologous to several human genes including PMPCB (peptidase, mitochondrial processing subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See UQCR-C1 in Genome Data Viewer
    Location:
    88D6-88D6; 3-56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14890231..14892387)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10715953..10718109)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cyclin C Neighboring gene Diphthamide biosynthesis 2 Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 93kD-2

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein processing involved in protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of mitochondrial processing peptidase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of respiratory chain complex III ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    Ubiquinol-cytochrome c reductase core protein 1
    Names
    CG3731-PA
    CG3731-PB
    UQCR-C1-PA
    UQCR-C1-PB
    Ubiquinol-cytochrome C reductase complex core protein I
    Ubiquinol-cytochrome c oxidoreductase core protein 1
    mitochondrial processing peptidase beta subunit
    mitochondrial-processing protease
    NP_650401.1
    NP_731954.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14890231..14892387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169607.2NP_731954.1  Ubiquinol-cytochrome c reductase core protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731954.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U87, Q9VFF0
      Related
      FBpp0082459
      Conserved Domains (1) summary
      COG0612
      Location:35459
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    2. NM_142144.3NP_650401.1  Ubiquinol-cytochrome c reductase core protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650401.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U87, Q9VFF0
      Related
      FBpp0082460
      Conserved Domains (1) summary
      COG0612
      Location:35459
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]