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    UQCR-C1 Ubiquinol-cytochrome c reductase core protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41800, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UQCR-C1provided by FlyBase
    Official Full Name
    Ubiquinol-cytochrome c reductase core protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038271
    Locus tag
    Dmel_CG3731
    See related
    AllianceGenome:FB:FBgn0038271
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 3731; CG3731; Dmel\CG3731; Mpp; MPPB; UCR1; UQCR-cp1; uqcrc1
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and mesoderm. Used to study late onset Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple mitochondrial dysfunctions syndrome 6. Orthologous to several human genes including PMPCB (peptidase, mitochondrial processing subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See UQCR-C1 in Genome Data Viewer
    Location:
    88D6-88D6; 3-56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14890231..14892387)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10715953..10718109)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cyclin C Neighboring gene Diphthamide biosynthesis 2 Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 93kD-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial UQCRC1 mutations cause autosomal dominant parkinsonism with polyneuropathy. Lin CH, et al. Brain, 2020 Dec 5. PMID 33141179, Free PMC Article
    2. Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation. Fernandez-Ayala DJ, et al. Cell Metab, 2009 May. PMID 19416715
    3. UQCRC1 engages cytochrome c for neuronal apoptotic cell death. Hung YC, et al. Cell Rep, 2021 Sep 21. PMID 34551295
    4. Practical Recommendations for the Use of the GeneSwitch Gal4 System to Knock-Down Genes in Drosophila melanogaster. Scialo F, et al. PLoS One, 2016. PMID 27570965, Free PMC Article
    5. Assembly of the complexes of oxidative phosphorylation triggers the remodeling of cardiolipin. Xu Y, et al. Proc Natl Acad Sci U S A, 2019 Jun 4. PMID 31110016, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UQCRC1 engages cytochrome c for neuronal apoptotic cell death.
      Title: UQCRC1 engages cytochrome c for neuronal apoptotic cell death.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing involved in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing involved in protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial processing peptidase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquinol-cytochrome c reductase core protein 1
    Names
    CG3731-PA
    CG3731-PB
    UQCR-C1-PA
    UQCR-C1-PB
    Ubiquinol-cytochrome C reductase complex core protein I
    Ubiquinol-cytochrome c oxidoreductase core protein 1
    mitochondrial processing peptidase beta subunit
    mitochondrial-processing protease
    NP_650401.1
    NP_731954.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14890231..14892387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169607.2 → NP_731954.1  Ubiquinol-cytochrome c reductase core protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731954.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U87, Q9VFF0
      Related
      FBpp0082459
      Conserved Domains (1) summary
      COG0612
      Location:35 → 459
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]

    2. NM_142144.3 → NP_650401.1  Ubiquinol-cytochrome c reductase core protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650401.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U87, Q9VFF0
      Related
      FBpp0082460
      Conserved Domains (1) summary
      COG0612
      Location:35 → 459
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFF0 Q9VFF0

    Gene LinkOut

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