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    Atf6 Atf6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35480, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atf6provided by FlyBase
    Official Full Name
    Atf6provided by FlyBase
    Primary source
    FLYBASE:FBgn0033010
    Locus tag
    Dmel_CG3136
    See related
    AllianceGenome:FB:FBgn0033010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atf6; ATF6; CG3136; DM15; Dmel\CG3136
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in endoplasmic reticulum unfolded protein response and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in germline cell; organism; pole plasm; and primordial germ cell. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to several human genes including ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Atf6 in Genome Data Viewer
    Location:
    41D4-41E1; 2-55 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5144733..5154756)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1032238..1042261)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43256 Neighboring gene gustavus Neighboring gene Nipped-A Neighboring gene long non-coding RNA:CR41443

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ER Stress Activates the TOR Pathway through Atf6. Allen D, et al. J Mol Signal, 2018 Apr 23. PMID 30210580, Free PMC Article
    2. ER Stress-Sensor Proteins and ER-Mitochondrial Crosstalk-Signaling Beyond (ER) Stress Response. Kumar V, et al. Biomolecules, 2021 Jan 28. PMID 33525374, Free PMC Article
    3. Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer's Disease. Zarini-Gakiye E, et al. CNS Neurol Disord Drug Targets, 2021. PMID 33573583
    4. Unfolded protein response in Drosophila: why another model can make it fly. Ryoo HD, et al. Cell Cycle, 2007 Apr 1. PMID 17387279
    5. Preservation of ∼12-h ultradian rhythms of gene expression of mRNA and protein metabolism in the absence of canonical circadian clock. Zhu B, et al. Front Physiol, 2023. PMID 37324401, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 5148076-5148127 mobile_element_type = transposon:INE-1{}2435
    • Loc: 5150040-5150239 mobile_element_type = transposon:INE-1{}2436
    • Loc: 5151525-5151586 mobile_element_type = transposon:INE-1{}2437
    • Loc: 5151980-5152474 mobile_element_type = transposon:Cr1a{}2561
    • Loc: 5154148-5154543 mobile_element_type = transposon:INE-1{}2439

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Atf6
    Names
    Atf6-PA
    Atf6-PB
    Atf6-PC
    CG3136-PA
    CG3136-PB
    CG3136-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5144733..5154756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165423.2 → NP_724403.1  Atf6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724403.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2V1
      Related
      FBpp0085415
      Conserved Domains (1) summary
      cd14700
      Location:285 → 336
      bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain

    2. NM_206023.2 → NP_995745.1  Atf6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995745.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX87
      Conserved Domains (1) summary
      cd14700
      Location:287 → 338
      bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain

    3. NM_136315.3 → NP_610159.1  Atf6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610159.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K2V1
      Related
      FBpp0085416
      Conserved Domains (1) summary
      cd14700
      Location:285 → 336
      bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K2V1 Q7K2V1
    Q8SX87 Q8SX87

    Gene LinkOut

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