Hacd1 3-hydroxyacyl-CoA dehydratase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hacd1provided by FlyBase
Official Full Name: 3-hydroxyacyl-CoA dehydratase 1provided by FlyBase
Primary source: FLYBASE:FBgn0032394
Locus tag: Dmel_CG6746
See related: AllianceGenome:FB:FBgn0032394
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6746; Dmel\CG6746; hacd1; HADC[CG6746]
Summary: Predicted to enable enzyme binding activity and very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; adult heart; embryonic dorsal epidermis; embryonic head epidermis; and gut section. Human ortholog(s) of this gene implicated in congenital myopathy. Orthologous to human HACD1 (3-hydroxyacyl-CoA dehydratase 1) and HACD2 (3-hydroxyacyl-CoA dehydratase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (12001234..12002266, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (12001234..12002266, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3-hydroxyacyl-CoA dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISS Inferred from Sequence or Structural Similarity more info
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fatty acid elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_609534.1

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The following sections contain reference sequences that belong to a specific genome build. Explain